Abnormal fear response and aggressive behavior in mutant mice deficient for α-calcium-calmodulin kinase II

Chong Chen, Donald G. Rainnie, Robert W. Greene, Susumu Tonegawa

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

Mice deficient for the gene encoding α-calcium-calmodulin-dependent kinase II (α-CaMKII knockout mice) provide a promising tool to link behavioral and cellular abnormalities with a specific molecular lesion. The heterozygous mouse exhibited a well-circumscribed syndrome of behavioral abnormalities, consisting primarily of a decreased fear response and an increase in defensive aggression, in the absence of any measured cognitive deficits. Unlike the heterozygote, the homozygote displayed abnormal behavior in all paradigms tested. At the cellular level, both extracellular and whole-cell patch clamp recordings indicated that serotonin release in putative serotonergic neurons of the dorsal raphe was reduced. Thus, α-CaMKII knockout mice, in particular the heterozygote, may provide a model for studying the molecular and cellular basis underlying emotional disorders involving fear and aggression.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalScience
Volume266
Issue number5183
StatePublished - Oct 14 1994

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Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Heterozygote
Aggression
Knockout Mice
Fear
Calcium
Serotonergic Neurons
Molecular Models
Homozygote
Serotonin
Genes
Dorsal Raphe Nucleus
Wells syndrome

ASJC Scopus subject areas

  • General

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Abnormal fear response and aggressive behavior in mutant mice deficient for α-calcium-calmodulin kinase II. / Chen, Chong; Rainnie, Donald G.; Greene, Robert W.; Tonegawa, Susumu.

In: Science, Vol. 266, No. 5183, 14.10.1994, p. 291-294.

Research output: Contribution to journalArticle

Chen, Chong ; Rainnie, Donald G. ; Greene, Robert W. ; Tonegawa, Susumu. / Abnormal fear response and aggressive behavior in mutant mice deficient for α-calcium-calmodulin kinase II. In: Science. 1994 ; Vol. 266, No. 5183. pp. 291-294.
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