Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition task

A. C. Lahti, H. H. Holcomb, D. R. Medoff, M. A. Weiler, C. A. Tamminga, Jr Carpenter W.T.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Objective: Using functional brain imaging, the authors sought to replicate their earlier finding of low metabolism in the middle frontal and inferior parietal cortices of schizophrenic patients with primary negative symptoms. Method: According to the presence or absence of enduring negative symptoms, patients with schizophrenia were classified as having deficit or nondeficit schizophrenia, respectively. Twelve normal volunteers and 18 drug-free schizophrenic volunteers (deficit, N=8; nondeficit, N=10) were trained in a tone discrimination task. They were trained to perform with 70%-80% accuracy and were then scanned with positron emission tomography with [15O] H2O during three conditions: rest, sensory-motor control task, and decision task. Results: Levels of performance of the auditory recognition task were similar in the three groups. An initial hypothesis-driven analysis revealed that across tasks the deficit group failed to show significant activation in the middle frontal cortex. This was in contrast to both the normal volunteers and nondeficit patients. When the patient groups were contrasted, the deficit patients showed significantly less activation in the middle frontal cortex bilaterally during the control task and in the right middle frontal cortex and inferior parietal cortex during the decision task. An exploratory analysis contrasting deficit and nondeficit patients across conditions did not reveal further differences between groups. Conclusions: This study replicated the finding of low activation in the middle frontal cortex and inferior parietal cortex in deficit schizophrenia. This deficit was observed without performance confound and may provide a marker of primary negative symptoms and a target for new therapies.

Original languageEnglish (US)
Pages (from-to)1797-1808
Number of pages12
JournalAmerican Journal of Psychiatry
Volume158
Issue number11
DOIs
StatePublished - 2001

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Cerebrovascular Circulation
Regional Blood Flow
Schizophrenia
Frontal Lobe
Parietal Lobe
Healthy Volunteers
Functional Neuroimaging
Positron-Emission Tomography
Volunteers

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition task. / Lahti, A. C.; Holcomb, H. H.; Medoff, D. R.; Weiler, M. A.; Tamminga, C. A.; Carpenter W.T., Jr.

In: American Journal of Psychiatry, Vol. 158, No. 11, 2001, p. 1797-1808.

Research output: Contribution to journalArticle

Lahti, A. C. ; Holcomb, H. H. ; Medoff, D. R. ; Weiler, M. A. ; Tamminga, C. A. ; Carpenter W.T., Jr. / Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition task. In: American Journal of Psychiatry. 2001 ; Vol. 158, No. 11. pp. 1797-1808.
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