Abstract
To determine if the inhibiting effect of glucopenia on arginine-stimulated insulin secretion is impaired at the onset of autoimmune diabetes, the insulin response to arginine was studied at 5.6 and 2.8 mmol/l glucose in perfused pancreata isolated from BB/W rats on the first day of diabetes and from age-matched diabetes-prone BB/W rats without diabetes. During glucopenia the baseline insulin secretion was reduced by more than 80% in both groups. However, the arginine-stimulated insulin response in the diabetic group was only 16.5% lower during glucopenia compared to 79.1% lower in the nondiabetic controls. Also, enhancement of the arginine-stimulated glucagon response by glucopenia was modest compared to controls. The results indicated that at the onset of this form of autoimmune diabetes the surviving B cells are, for unknown reasons, hyperresponsive to arginine and that, in contrast to the controls, this response is not inhibited by glucopenia.
Original language | English (US) |
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Pages (from-to) | 225-227 |
Number of pages | 3 |
Journal | Diabetologia |
Volume | 31 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1988 |
Keywords
- BB/W rats
- Glucopenia
- arginine
- diabetes
- glucagon
- insulin
- perfused pancreas
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism