Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450

Jorge Capdevila, Pendri Yadagiri, Sukumar Manna, J. R. Falck

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.

Original languageEnglish (US)
Pages (from-to)1007-1011
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume141
Issue number3
DOIs
StatePublished - Dec 30 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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