Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450

Jorge Capdevila; Pendri Yadagiri; Sukumar Manna; J. R. Falck

doi:10.1016/S0006-291X(86)80144-9

Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450

Jorge Capdevila, Pendri Yadagiri, Sukumar Manna, J. R. Falck

Biochemistry

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.

Original language	English (US)
Pages (from-to)	1007-1011
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	141
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(86)80144-9
State	Published - Dec 30 1986

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/S0006-291X(86)80144-9

Cite this

Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450. / Capdevila, Jorge; Yadagiri, Pendri; Manna, Sukumar et al.
In: Biochemical and Biophysical Research Communications, Vol. 141, No. 3, 30.12.1986, p. 1007-1011.

Research output: Contribution to journal › Article › peer-review

@article{8b35da48536b4d6ab84ad300f41e94d5,

title = "Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450",

abstract = "Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.",

author = "Jorge Capdevila and Pendri Yadagiri and Sukumar Manna and Falck, {J. R.}",

note = "Funding Information: Acknowledgments: Supported in part by grants NIGMS 33541, and the Robert A. Welch Foundation (I-782).",

year = "1986",

month = dec,

day = "30",

doi = "10.1016/S0006-291X(86)80144-9",

language = "English (US)",

volume = "141",

pages = "1007--1011",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450

AU - Capdevila, Jorge

AU - Yadagiri, Pendri

AU - Manna, Sukumar

AU - Falck, J. R.

N1 - Funding Information: Acknowledgments: Supported in part by grants NIGMS 33541, and the Robert A. Welch Foundation (I-782).

PY - 1986/12/30

Y1 - 1986/12/30

N2 - Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.

AB - Rat liver microsomal cytochrome P-450 catalyzes the NADPH dependent metabolism of arachidonic acid to six regioisomeric cis,trans-dienols. The 12(R)-hydroxyeicosatetraenoic acid is generated with a high degree of enantioselectivity while the remaining regioisomers are produced as nearly racemic mixtures.

UR - http://www.scopus.com/inward/record.url?scp=0022907609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022907609&partnerID=8YFLogxK

U2 - 10.1016/S0006-291X(86)80144-9

DO - 10.1016/S0006-291X(86)80144-9

M3 - Article

C2 - 3101677

AN - SCOPUS:0022907609

SN - 0006-291X

VL - 141

SP - 1007

EP - 1011

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this