Acanthopanax senticosus: Review of botany, chemistry and pharmacology

Lin Zhang Huang, Hong Fang Zhao, Bao Kang Huang, Cheng Jian Zheng, Wei Peng, Lu Ping Qin

Research output: Contribution to journalReview article

Abstract

Acanthopanax senticosus (Rupr. et Maxim) Harms (Araliaceae), also called Siberian Ginseng, Eleutherococcus senticosus, and Ciwujia in Chinese, is a widely used traditional Chinese herb that could invigorate qi, strengthen the spleen, and nourish kidney in the theory of Traditional Chinese Medicine. With high medicinal value, Acanthopanax senticosus (AS, thereafter) is popularly used as an "adaptogen" like Panax ginseng. In recent decades, a great number of chemical, pharmacological, and clinical studies on AS have been carried out worldwide. Several kinds of chemical compounds have been reported, including triterpenoid saponins, lignans, coumarins, and flavones, among which, phenolic compounds such as syringin and eleutheroside E, were considered to be the most active components. Considerable pharmacological experiments both in vitro and in vivo have persuasively demonstrated that AS possessed anti-stress, anti-ulcer, anti-irradiation, anticancer, anti-inflammatory and hepatoprotective activities, etc. The present review is an up-to-date and comprehensive analysis of the botany, chemistry, pharmacology, toxicity and clinical trials of AS.

Original languageEnglish (US)
Pages (from-to)83-97
Number of pages15
JournalPharmazie
Volume66
Issue number2
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Huang, L. Z., Zhao, H. F., Huang, B. K., Zheng, C. J., Peng, W., & Qin, L. P. (2011). Acanthopanax senticosus: Review of botany, chemistry and pharmacology. Pharmazie, 66(2), 83-97. https://doi.org/10.1691/ph.2011.0744