Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1

Frédérique Gay, Dominica Calvo, Miao Chia Lo, Julian Ceron, Morris Maduro, Rueyling Lin, Yang Shi

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Lymphoid enhancer factor/T-cell factor (LEF/TCF) are transcription factors that mediate the Wnt signaling pathway, and have crucial roles during embryonic development in various organisms. Here we report that acetylation enhances nuclear retention of POP-1, the Caenorhabditis elegans LEF/TCF homolog, through increasing nuclear import and blocking nuclear export. We identify three lysines that are acetylated in vivo, and demonstrate their essential requirement for proper nuclear localization and biological activity of POP-1 during C. elegans embryogenesis. The conservation of these lysines among other LEF/TCF family members suggests that acetylation may be an important, evolutionarily conserved mechanism regulating subcellular distribution of LEF/TCF factors.

Original languageEnglish (US)
Pages (from-to)717-722
Number of pages6
JournalGenes and Development
Volume17
Issue number6
DOIs
StatePublished - Mar 15 2003

Keywords

  • Acetylation
  • C. elegans
  • CBP-1
  • LEF/TCF
  • POP-1
  • Wnt

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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    Gay, F., Calvo, D., Lo, M. C., Ceron, J., Maduro, M., Lin, R., & Shi, Y. (2003). Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1. Genes and Development, 17(6), 717-722. https://doi.org/10.1101/gad.1042403