Acinus: A nuclear regulator of autophagy and endocytic trafficking

Research output: Contribution to journalShort surveypeer-review

Abstract

Fusion with lysosomes is the common last step of endocytic trafficking and autophagy. Accordingly, several proteins are required in both pathways for cargoes to reach their destinations. Among these proteins, Drosophila Acinus stands out, as it exerts opposite effects on these two pathways, and thus establishes a new paradigm. Loss of Acinus function destabilizes early endosomes, thereby promoting the delivery of their cargo to lysosomes. By contrast, the maturation of autophagosomes to autolysosomes is inhibited in acn mutant cells. The increase in autophagy upon Acinus overexpression and its location to the nucleus are consistent with Acinus being a novel regulator of autophagy.

Original languageEnglish (US)
Pages (from-to)974-975
Number of pages2
JournalAutophagy
Volume6
Issue number7
DOIs
StatePublished - Oct 1 2010

Keywords

  • EGF receptor
  • Endosomes
  • Fat body
  • Lysosomes
  • Notch signaling
  • Nuclear protein

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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