Actinic keratoses and the incidence of occult squamous cell carcinoma: A clinical-histopathologic correlation

Torsten Ehrig, Clay Cockerell, Daniel Piacquadio, Syd Dromgoole

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

BACKGROUND: The ability to clinically diagnose actinic keratoses (AKs) lesions has been taken for granted for some time. The importance of the malignant potential of these lesions is well known. However, a recent Phase IV, multicenter study assessing the long-term benefit of aminolevulinic acid-based photodynamic therapy provided a unique opportunity to prospectively examine the clinical histopathologic correlation of AKs. OBJECTIVE: The objective was to characterize the histopathology of clinically diagnosed AK lesions in the study population. METHODS: Punch biopsies of 220 clinically diagnosed untreated AKs were performed at baseline plus 51 lesions unresponsive to treatment (total, 271). RESULTS: Clinical diagnosis and histopathologic findings agreed in 91% (246/271) of the lesions biopsied. The balance of the biopsied lesions were: (1) benign changes 4% (11/271) and (2) occult cutaneous malignancy in 5% (14/271) of the cases, 12 squamous cell carcinomas and 2 basal cell carcinomas. CONCLUSIONS: In this study, about 1 in 25 clinically diagnosed AK lesions identified by board-certified dermatologist investigator(s) were occult early-stage squamous cell carcinomas on histologic assessment, a fact surmised by the medical community that until now had not been well quantified. These findings should be considered when clinicians decide how to treat and manage AK patients.

Original languageEnglish (US)
Pages (from-to)1261-1265
Number of pages5
JournalDermatologic Surgery
Volume32
Issue number10
DOIs
StatePublished - Oct 2006

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Actinic Keratosis
Squamous Cell Carcinoma
Incidence
Aminolevulinic Acid
Basal Cell Carcinoma
Photochemotherapy
Multicenter Studies
Research Personnel
Biopsy
Skin
Population
Neoplasms

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Actinic keratoses and the incidence of occult squamous cell carcinoma : A clinical-histopathologic correlation. / Ehrig, Torsten; Cockerell, Clay; Piacquadio, Daniel; Dromgoole, Syd.

In: Dermatologic Surgery, Vol. 32, No. 10, 10.2006, p. 1261-1265.

Research output: Contribution to journalArticle

Ehrig, Torsten ; Cockerell, Clay ; Piacquadio, Daniel ; Dromgoole, Syd. / Actinic keratoses and the incidence of occult squamous cell carcinoma : A clinical-histopathologic correlation. In: Dermatologic Surgery. 2006 ; Vol. 32, No. 10. pp. 1261-1265.
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