Activated Acinus boosts basal autophagy

Nilay Nandi, Lauren K. Tyra, Helmut Krämer

Research output: Contribution to journalComment/debatepeer-review


Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn activity is enhanced by Akt1-mediated phosphorylation, which counteracts the cleavage of Acn by a caspase-3 homolog.

Original languageEnglish (US)
Article numbere995043
JournalMolecular and Cellular Oncology
Issue number3
StatePublished - Jul 3 2015

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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