Activated Acinus boosts basal autophagy

Nilay Nandi, Lauren K. Tyra, Helmut Krämer

Research output: Contribution to journalComment/debate

Abstract

Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn activity is enhanced by Akt1-mediated phosphorylation, which counteracts the cleavage of Acn by a caspase-3 homolog.

Original languageEnglish (US)
Article numbere995043
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
Publication statusPublished - Jul 3 2015

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ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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