Activated brown adipose tissue and its relationship to adiposity and metabolic markers: an exploratory study

Malini Soundarrajan; Jie Deng; Mary Kwasny; Nicholas C. Rubert; Paige C. Nelson; Dalya A. El-Seoud; Lewis Landsberg; Lisa M. Neff

doi:10.1080/21623945.2020.1724740

Activated brown adipose tissue and its relationship to adiposity and metabolic markers: an exploratory study

Malini Soundarrajan, Jie Deng, Mary Kwasny, Nicholas C. Rubert, Paige C. Nelson, Dalya A. El-Seoud, Lewis Landsberg, Lisa M. Neff

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Objective: To explore relationships between PET/CT characteristics of cold-activated brown adipose tissue (BAT), measures of adiposity and metabolic markers. Methods: We conducted a post-hoc analysis of a study which utilized PET/CT to characterize BAT. 25 men ages 18–24 (BMI 19.4 to 35.9 kg/m²) were studied. Fasting blood samples were collected. Body composition was measured using DXA. An individualized cooling protocol was utilized to activate BAT prior to imaging with PET/CT. Results: There was an inverse relationship between fasting serum glucose and BAT volume (r = −0.40, p = 0.048). A marginally significant inverse relationship was also noted between fasting glucose and total BAT activity (r = −0.40, p = 0.05). In addition, a positive correlation was observed between serum FGF21 and SUV_max (r = 0.51, p = 0.01). No significant correlations were noted for measures of BAT activity or volume and other indicators of adiposity or glucose metabolism. Conclusions: The presence of active BAT may be associated with lower fasting glucose in young men. BAT activity may also be correlated with levels of FGF21, suggesting that BAT may lower glucose levels via an FGF21 dependent pathway. Further studies are needed to clarify mechanisms by which BAT may impact glucose metabolism.

Original language	English (US)
Pages (from-to)	87-95
Number of pages	9
Journal	Adipocyte
Volume	9
Issue number	1
DOIs	https://doi.org/10.1080/21623945.2020.1724740
State	Published - Jan 1 2020
Externally published	Yes

Keywords

Brown adipose tissue
adiposity
metabolism

ASJC Scopus subject areas

Histology
Cell Biology

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10.1080/21623945.2020.1724740

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@article{48a9cc55ae7d466b8155907fa5103942,

title = "Activated brown adipose tissue and its relationship to adiposity and metabolic markers: an exploratory study",

abstract = "Objective: To explore relationships between PET/CT characteristics of cold-activated brown adipose tissue (BAT), measures of adiposity and metabolic markers. Methods: We conducted a post-hoc analysis of a study which utilized PET/CT to characterize BAT. 25 men ages 18–24 (BMI 19.4 to 35.9 kg/m2) were studied. Fasting blood samples were collected. Body composition was measured using DXA. An individualized cooling protocol was utilized to activate BAT prior to imaging with PET/CT. Results: There was an inverse relationship between fasting serum glucose and BAT volume (r = −0.40, p = 0.048). A marginally significant inverse relationship was also noted between fasting glucose and total BAT activity (r = −0.40, p = 0.05). In addition, a positive correlation was observed between serum FGF21 and SUVmax (r = 0.51, p = 0.01). No significant correlations were noted for measures of BAT activity or volume and other indicators of adiposity or glucose metabolism. Conclusions: The presence of active BAT may be associated with lower fasting glucose in young men. BAT activity may also be correlated with levels of FGF21, suggesting that BAT may lower glucose levels via an FGF21 dependent pathway. Further studies are needed to clarify mechanisms by which BAT may impact glucose metabolism.",

keywords = "Brown adipose tissue, adiposity, metabolism",

author = "Malini Soundarrajan and Jie Deng and Mary Kwasny and Rubert, {Nicholas C.} and Nelson, {Paige C.} and El-Seoud, {Dalya A.} and Lewis Landsberg and Neff, {Lisa M.}",

note = "Funding Information: for the study was provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [grant number: 1R21DK103145-01]; and MS was supported by Ruth L. Kirschstein National Research Service Award [T32 DK007169] from the NIDDK. Funding Information: LMN has received unrelated research funding from Aegerion Pharmaceuticals and has been a Research Investigator for Novo Nordisk. No potential conflict of interest was reported by other authors. Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2020",

month = jan,

day = "1",

doi = "10.1080/21623945.2020.1724740",

language = "English (US)",

volume = "9",

pages = "87--95",

journal = "Adipocyte",

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T1 - Activated brown adipose tissue and its relationship to adiposity and metabolic markers

T2 - an exploratory study

AU - Soundarrajan, Malini

AU - Deng, Jie

AU - Kwasny, Mary

AU - Rubert, Nicholas C.

AU - Nelson, Paige C.

AU - El-Seoud, Dalya A.

AU - Landsberg, Lewis

AU - Neff, Lisa M.

N1 - Funding Information: for the study was provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [grant number: 1R21DK103145-01]; and MS was supported by Ruth L. Kirschstein National Research Service Award [T32 DK007169] from the NIDDK. Funding Information: LMN has received unrelated research funding from Aegerion Pharmaceuticals and has been a Research Investigator for Novo Nordisk. No potential conflict of interest was reported by other authors. Publisher Copyright: © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Objective: To explore relationships between PET/CT characteristics of cold-activated brown adipose tissue (BAT), measures of adiposity and metabolic markers. Methods: We conducted a post-hoc analysis of a study which utilized PET/CT to characterize BAT. 25 men ages 18–24 (BMI 19.4 to 35.9 kg/m2) were studied. Fasting blood samples were collected. Body composition was measured using DXA. An individualized cooling protocol was utilized to activate BAT prior to imaging with PET/CT. Results: There was an inverse relationship between fasting serum glucose and BAT volume (r = −0.40, p = 0.048). A marginally significant inverse relationship was also noted between fasting glucose and total BAT activity (r = −0.40, p = 0.05). In addition, a positive correlation was observed between serum FGF21 and SUVmax (r = 0.51, p = 0.01). No significant correlations were noted for measures of BAT activity or volume and other indicators of adiposity or glucose metabolism. Conclusions: The presence of active BAT may be associated with lower fasting glucose in young men. BAT activity may also be correlated with levels of FGF21, suggesting that BAT may lower glucose levels via an FGF21 dependent pathway. Further studies are needed to clarify mechanisms by which BAT may impact glucose metabolism.

AB - Objective: To explore relationships between PET/CT characteristics of cold-activated brown adipose tissue (BAT), measures of adiposity and metabolic markers. Methods: We conducted a post-hoc analysis of a study which utilized PET/CT to characterize BAT. 25 men ages 18–24 (BMI 19.4 to 35.9 kg/m2) were studied. Fasting blood samples were collected. Body composition was measured using DXA. An individualized cooling protocol was utilized to activate BAT prior to imaging with PET/CT. Results: There was an inverse relationship between fasting serum glucose and BAT volume (r = −0.40, p = 0.048). A marginally significant inverse relationship was also noted between fasting glucose and total BAT activity (r = −0.40, p = 0.05). In addition, a positive correlation was observed between serum FGF21 and SUVmax (r = 0.51, p = 0.01). No significant correlations were noted for measures of BAT activity or volume and other indicators of adiposity or glucose metabolism. Conclusions: The presence of active BAT may be associated with lower fasting glucose in young men. BAT activity may also be correlated with levels of FGF21, suggesting that BAT may lower glucose levels via an FGF21 dependent pathway. Further studies are needed to clarify mechanisms by which BAT may impact glucose metabolism.

KW - Brown adipose tissue

KW - adiposity

KW - metabolism

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JO - Adipocyte

JF - Adipocyte

IS - 1

ER -

Activated brown adipose tissue and its relationship to adiposity and metabolic markers: an exploratory study

Abstract

Keywords

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