129 Citations (Scopus)

Abstract

The purpose of this investigation was to determine whether there were differences in the magnitude of insular cortex activation across varying intensities of static and dynamic exercise. Eighteen healthy volunteers were studied: eight during two intensities of leg cycling and ten at different time periods during sustained static handgrip at 25% maximal voluntary contraction or postexercise cuff occlusion. Heart rate, blood pressure (BP), perceived exertion, and regional cerebral blood flow (rCBF) distribution data were collected. There were significantly greater increases in insular rCBF during lower (6.3 ± 1.7%; P < 0.05) and higher (13.3 ± 3.8%; P < 0.05) intensity cycling and across time during static handgrip (change from rest for right insula at 2-3 min, 3.8 ± 1.1%, P < 0.05; and at 4-5 min, 8.6 ± 2.8%, P < 0.05). Insular rCBF was decreased during postexercise cuff occlusion (-5.5 ± 1.2%; P < 0.05) with BP sustained at exercise levels. Right insular rCBF data, but not left, were significantly related, with individual BP changes (r2 = 0.80; P < 0.001) and with ratings of perceived exertion (r2 = 0.79; P < 0.01) during exercise. These results suggest that the magnitude of insular activation varies with the intensity of exercise, which may be further related to the level of perceived effort or central command.

Original languageEnglish (US)
Pages (from-to)1213-1219
Number of pages7
JournalJournal of Applied Physiology
Volume87
Issue number3
StatePublished - Sep 1999

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Cerebral Cortex
Exercise
Blood Pressure
Leg
Healthy Volunteers
Heart Rate

Keywords

  • Autonomic nervous system
  • Brain
  • Human
  • Magnetic resonance imaging
  • Single-photon emission-computed tomography

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Activation of the insular cortex is affected by the intensity of exercise. / Williamson, J. W.; McColl, R.; Mathews, D.; Ginsburg, M.; Mitchell, J. H.

In: Journal of Applied Physiology, Vol. 87, No. 3, 09.1999, p. 1213-1219.

Research output: Contribution to journalArticle

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