Active and passive immunotherapy against tau: Effects and potential mechanisms

Kiran Yanamandra, Marc I. Diamond, David M. Holtzman

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The aggregation, hyperphosphorylation, and accumulation of the microtubule-associated protein tau is a hallmark for several neurodegenerative diseases, including Alzheimer’s disease. These diseases are known as tauopathies. In tauopathies, the tau protein becomes hyperphosphorylated and forms intracellular neurofibrillary tangles visualized within dystrophic neurites and cell bodies. Evidence suggests that some tau aggregates can become extracellular where they potentially propagate between cells and induce tau pathology in previously unaffected cells. The amount of tau pathology correlates well with the load of neurofibrillary tangles, synaptic loss, and functional decline in humans as well as in transgenic mouse models of tauopathy. Several active and passive immunization studies targeting tau in transgenic mouse models have shown reduced tau pathology, although the mechanism(s) underlying these effects is not clear. In this chapter, we review the recent active and passive immunization strategies targeting tau in mouse models and our understanding of potential mechanisms underlying the effects seen.

Original languageEnglish (US)
Title of host publicationMethods in Pharmacology and Toxicology
PublisherHumana Press Inc.
Pages121-138
Number of pages18
DOIs
StatePublished - Jan 1 2016

Publication series

NameMethods in Pharmacology and Toxicology
VolumePartF1
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053

Keywords

  • Alzheimer’s disease
  • Antibody
  • Immunotherapy
  • Neurodegeneration
  • Tau

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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