Acute changes in endothelin-1 after hemodialysis for chronic renal failure

R. D. Ross, V. Kalidindi, J. A. Vincent, J. Kassab, S. Dabbagh, J. M. Hsu, W. W. Pinsky

Research output: Contribution to journalArticle

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Abstract

Endothelin is a recently described, potent renal vascular and systemic vasoconstrictor peptide. To evaluate the response of this peptide to volume contraction, we measured eight baseline and posthemodialysis samples from seven children, aged 14.5 ± 3 years, with chronic renal failure. Plasma was extracted and endothelin-1 was measured by radioimmunoassay. Dialysis was performed for a 3- to 3 1/2 -hour period, and body weight decreased from 38.0 ± 14.3 to 36.2 ± 13.8 kg (p < 0.01) during this time. There were no significant changes in heart rate or respiratory rate after dialysis, but blood pressure fell from 127/80 ± 22/16 to 114/72 ± 20/21 mm Hg (p = 0.05 for the systolic pressure). Plasma endotheli8n-1 concentration increased from 1.5 ± 1.2 pg/ml at baseline to 7.3 ± 8.9 pg/ml (p = 0.06) after dialysis; the fall in body weight from dialysis correlated with the increase in endothelin (r = -0.75; p = 0.05). Thus volume contraction from hemodialysis is associated with a rise in plasma endothelin-1, which is related to the acute change in body weight.

Original languageEnglish (US)
JournalJournal of Pediatrics
Volume122
Issue number6
StatePublished - 1993

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Endothelin-1
Chronic Kidney Failure
Renal Dialysis
Dialysis
Endothelins
Body Weight
Blood Pressure
Peptides
Body Weight Changes
Vasoconstrictor Agents
Respiratory Rate
Radioimmunoassay
Blood Vessels
Heart Rate
Kidney

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Ross, R. D., Kalidindi, V., Vincent, J. A., Kassab, J., Dabbagh, S., Hsu, J. M., & Pinsky, W. W. (1993). Acute changes in endothelin-1 after hemodialysis for chronic renal failure. Journal of Pediatrics, 122(6).

Acute changes in endothelin-1 after hemodialysis for chronic renal failure. / Ross, R. D.; Kalidindi, V.; Vincent, J. A.; Kassab, J.; Dabbagh, S.; Hsu, J. M.; Pinsky, W. W.

In: Journal of Pediatrics, Vol. 122, No. 6, 1993.

Research output: Contribution to journalArticle

Ross, RD, Kalidindi, V, Vincent, JA, Kassab, J, Dabbagh, S, Hsu, JM & Pinsky, WW 1993, 'Acute changes in endothelin-1 after hemodialysis for chronic renal failure', Journal of Pediatrics, vol. 122, no. 6.
Ross RD, Kalidindi V, Vincent JA, Kassab J, Dabbagh S, Hsu JM et al. Acute changes in endothelin-1 after hemodialysis for chronic renal failure. Journal of Pediatrics. 1993;122(6).
Ross, R. D. ; Kalidindi, V. ; Vincent, J. A. ; Kassab, J. ; Dabbagh, S. ; Hsu, J. M. ; Pinsky, W. W. / Acute changes in endothelin-1 after hemodialysis for chronic renal failure. In: Journal of Pediatrics. 1993 ; Vol. 122, No. 6.
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