Acute Hypervitaminosis A in Guinea Pigs. I. Effects on Acid Hydrolases

G. WEISSMANN, J. W. UHR, L. THOMAS

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Acute hypervitaminosis A was induced in guinea pigs by oral administration of Vit. A. This treatment caused much of the activity of acid phosphatase, beta-glucuronidase and cathepsin to become unsedimentable at 15,000 g in homogenates prepared in 0.25M sucrose. Lysosome-rich fractions of hypervitaminotic livers released beta-glucuronidase and cathepsin more readily into the incubation medium in vitro than did control fractions. These events were accompanied by increases of serum beta-glucuronidase, and are compatible with a direct effect of excess Vit. A on lysosomes.

Original languageEnglish (US)
Pages (from-to)284-287
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume112
Issue number2
DOIs
StatePublished - Feb 1963

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Acute Hypervitaminosis A in Guinea Pigs. I. Effects on Acid Hydrolases'. Together they form a unique fingerprint.

Cite this