Acute hypervitaminosis A was induced in guinea pigs by oral administration of Vit. A. This treatment caused much of the activity of acid phosphatase, beta-glucuronidase and cathepsin to become unsedimentable at 15,000 g in homogenates prepared in 0.25M sucrose. Lysosome-rich fractions of hypervitaminotic livers released beta-glucuronidase and cathepsin more readily into the incubation medium in vitro than did control fractions. These events were accompanied by increases of serum beta-glucuronidase, and are compatible with a direct effect of excess Vit. A on lysosomes.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Feb 1963|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)