Acute kidney injury: A conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules

Christopher Y. Lu, Pamela D. Winterberg, Jianlin Chen, John R. Hartono

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia-reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal-spatial roles and potential therapeutics targeting this particular receptor-ligand interaction are also explored.

Original languageEnglish (US)
Pages (from-to)1847-1854
Number of pages8
JournalPediatric Nephrology
Volume27
Issue number10
DOIs
StatePublished - Oct 2012

Fingerprint

Toll-Like Receptor 4
Acute Kidney Injury
Endothelium
Leukocytes
HMGB1 Protein
Ligands
Reperfusion Injury
Innate Immunity
Kidney Transplantation
Inflammation
Morbidity
Mortality
Wounds and Injuries
Therapeutics

Keywords

  • Damage associated molecular patterns
  • Innate immunity
  • Ischemic acute kidney injury
  • Toll-like receptor
  • Transplant rejection

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Acute kidney injury : A conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules. / Lu, Christopher Y.; Winterberg, Pamela D.; Chen, Jianlin; Hartono, John R.

In: Pediatric Nephrology, Vol. 27, No. 10, 10.2012, p. 1847-1854.

Research output: Contribution to journalArticle

Lu, Christopher Y. ; Winterberg, Pamela D. ; Chen, Jianlin ; Hartono, John R. / Acute kidney injury : A conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules. In: Pediatric Nephrology. 2012 ; Vol. 27, No. 10. pp. 1847-1854.
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