Acute liver failure: A curable disease by 2024?

William Bernal, William M. Lee, Julia Wendon, Fin Stolze Larsen, Roger Williams

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Over the last three decades acute liver failure (ALF) has been transformed from a rare and poorly understood condition with a near universally fatal outcome, to one with a well characterized phenotype and disease course. Complex critical care protocols are now applied and emergency liver transplantation (ELT) is an established treatment option. These improvements in care are such that the majority of patients may now be expected to survive (Fig. 1). Key features of the condition have changed dramatically over time, with a remarkable fall in the incidence of cerebral edema and intracranial hypertension, a much feared complication. In this review, we summarize the current understanding of key aspects of the classification, pathophysiology and management of ALF, and discuss the foreseeable challenges that will need to be addressed for further improvements to be achieved.

Original languageEnglish (US)
Pages (from-to)S112-S120
JournalJournal of Hepatology
Volume62
Issue numberS1
DOIs
StatePublished - 2015

Fingerprint

Acute Liver Failure
Intracranial Hypertension
Fatal Outcome
Brain Edema
Critical Care
Liver Transplantation
Emergencies
Phenotype
Incidence
Therapeutics

Keywords

  • Acute liver failure
  • Ammonia
  • Cerebral edema
  • Transplantation

ASJC Scopus subject areas

  • Hepatology

Cite this

Bernal, W., Lee, W. M., Wendon, J., Larsen, F. S., & Williams, R. (2015). Acute liver failure: A curable disease by 2024? Journal of Hepatology, 62(S1), S112-S120. https://doi.org/10.1016/j.jhep.2014.12.016

Acute liver failure : A curable disease by 2024? / Bernal, William; Lee, William M.; Wendon, Julia; Larsen, Fin Stolze; Williams, Roger.

In: Journal of Hepatology, Vol. 62, No. S1, 2015, p. S112-S120.

Research output: Contribution to journalArticle

Bernal, W, Lee, WM, Wendon, J, Larsen, FS & Williams, R 2015, 'Acute liver failure: A curable disease by 2024?', Journal of Hepatology, vol. 62, no. S1, pp. S112-S120. https://doi.org/10.1016/j.jhep.2014.12.016
Bernal, William ; Lee, William M. ; Wendon, Julia ; Larsen, Fin Stolze ; Williams, Roger. / Acute liver failure : A curable disease by 2024?. In: Journal of Hepatology. 2015 ; Vol. 62, No. S1. pp. S112-S120.
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