Acute Stroke Imaging Research Roadmap III Imaging Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials: Consensus Recommendations and Further Research Priorities

Steven J. Warach, Marie Luby, Gregory W. Albers, Roland Bammer, Andrew Bivard, Bruce C V Campbell, Colin Derdeyn, Jeremy J. Heit, Pooja Khatri, Maarten G. Lansberg, David S. Liebeskind, Charles B L M Majoie, Michael P. Marks, Bijoy K. Menon, Keith W. Muir, Mark W. Parsons, Achala Vagal, Albert J. Yoo, Andrei V. Alexandrov, Jean Claude BaronDavid J. Fiorella, Anthony J. Furlan, Josep Puig, Peter D. Schellinger, Max Wintermark

Research output: Contribution to journalArticle

43 Scopus citations


Background and Purpose - The Stroke Imaging Research (STIR) group, the Imaging Working Group of StrokeNet, the American Society of Neuroradiology, and the Foundation of the American Society of Neuroradiology sponsored an imaging session and workshop during the Stroke Treatment Academy Industry Roundtable (STAIR) IX on October 5 to 6, 2015 in Washington, DC. The purpose of this roadmap was to focus on the role of imaging in future research and clinical trials. Methods - This forum brought together stroke neurologists, neuroradiologists, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke (NINDS), industry representatives, and members of the US Food and Drug Administration to discuss STIR priorities in the light of an unprecedented series of positive acute stroke endovascular therapy clinical trials. Results - The imaging session summarized and compared the imaging components of the recent positive endovascular trials and proposed opportunities for pooled analyses. The imaging workshop developed consensus recommendations for optimal imaging methods for the acquisition and analysis of core, mismatch, and collaterals across multiple modalities, and also a standardized approach for measuring the final infarct volume in prospective clinical trials. Conclusions - Recent positive acute stroke endovascular clinical trials have demonstrated the added value of neurovascular imaging. The optimal imaging profile for endovascular treatment includes large vessel occlusion, smaller core, good collaterals, and large penumbra. However, equivalent definitions for the imaging profile parameters across modalities are needed, and a standardization effort is warranted, potentially leveraging the pooled data resulting from the recent positive endovascular trials.

Original languageEnglish (US)
Pages (from-to)1389-1398
Number of pages10
Issue number5
Publication statusPublished - May 1 2016



  • angiography
  • clinical trial
  • ischemia
  • reperfusion
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

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