ADCY7 supports development of acute myeloid leukemia

Chunling Li, Jingjing Xie, Zhigang Lu, Chen Chen, Yancun Yin, Renhui Zhan, Yi Fang, Xuemei Hu, Chengcheng Zhang

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Acute myeloid leukemia (AML) is the most common adult acute leukemia. Despite treatment, the majority of the AML patients relapse within 5 years. In silico analysis of several available databases of AML patients showed that the expression of adenylate cyclase 7 (ADCY7) significantly inversely correlates with the overall survival of AML patients. To determine whether ADCY7 supports AML development, we employed an shRNA-encoding lentivirus system to inhibit adcy7 expression in human AML cells including U937, MV4-11, and THP-1 cells. The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression of these leukemia cells. This indicates that G protein-coupled receptor signaling contributes to AML pathogenesis. Our study suggests that inhibition of ADCY7 may be novel strategy for treating leukemia.

Original languageEnglish (US)
Article number34335
Pages (from-to)47-52
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume465
Issue number1
DOIs
Publication statusPublished - Jul 26 2015

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Keywords

  • Acute myeloid leukemia
  • ADCY7
  • Apoptosis
  • Cell growth
  • G protein-coupled receptor
  • shRNA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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