Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone

Gerald A. Marks, Christian G. Birabil, Samuel G. Speciale

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Microinjection of adenosine A1 receptor agonist or an inhibitor of adenylyl cyclase into the caudal, oral pontine reticular formation (PnOc) of the rat induces a long-lasting increase in REM sleep. Here, we report significant inhibition of forskolin-stimulated cAMP in dissected pontine tissue slices containing the PnOc incubated with the A1 receptor agonist, cyclohexaladenosine (10-8 M). These data are consistent with adenosine A1 receptor agonist actions on REM sleep mediated through inhibition of cAMP.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalBrain Research
Volume1061
Issue number2
DOIs
StatePublished - Nov 9 2005

Keywords

  • Adenylyl cylase
  • Cyclohexaladenosine
  • Forskolin
  • Pontine reticular formation
  • Pontine slice

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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