Abstract
The prevalence of obesity has increased dramatically in recent decades, reaching epidemic proportions. It is becoming clear that obesity is associated not only with type 2 diabetes mellitus and cardiovascular disease, but also with multiple types of cancer. Obesity is characterized by impaired adipose tissue function, leading to adipocyte hypertrophy, inflammation, hypoxia and induced angiogenesis, extracellular matrix remodeling and fibrosis as well as additional stress responses. While epidemiological data indicate that obesity is a well-established risk factor for certain malignancies, the molecular mechanisms underlying the link between obesity and cancer are still poorly understood. Recent data implicates systemic and paracrine factors secreted from adipose tissue during the obese state, promoting cancer development and progression. Here, we focus on the obesity-associated adipose tissue remodeling that may not only lead to metabolic complications, but also to a permissive pro-tumorigenic environment. Particular attention is given to the local pro-tumorigenic effects derived from adipocytes that present an important part of the tumor microenvironment of at least some cancers, in an attempt to describe the nature of the major players of the adipocyte-cancer cell crosstalk that dictates to a large extent tumor progression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 197-210 |
| Number of pages | 14 |
| Journal | Pharmacology and Therapeutics |
| Volume | 138 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 2013 |
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Keywords
- Adipocyte
- Cancer metabolism
- Obesity
- Stromal compartment
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Adipocytes : Impact on tumor growth and potential sites for therapeutic intervention. / Hefetz-Sela, Simona; Scherer, Philipp E.
In: Pharmacology and Therapeutics, Vol. 138, No. 2, 05.2013, p. 197-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adipocytes
T2 - Impact on tumor growth and potential sites for therapeutic intervention
AU - Hefetz-Sela, Simona
AU - Scherer, Philipp E.
PY - 2013/5
Y1 - 2013/5
N2 - The prevalence of obesity has increased dramatically in recent decades, reaching epidemic proportions. It is becoming clear that obesity is associated not only with type 2 diabetes mellitus and cardiovascular disease, but also with multiple types of cancer. Obesity is characterized by impaired adipose tissue function, leading to adipocyte hypertrophy, inflammation, hypoxia and induced angiogenesis, extracellular matrix remodeling and fibrosis as well as additional stress responses. While epidemiological data indicate that obesity is a well-established risk factor for certain malignancies, the molecular mechanisms underlying the link between obesity and cancer are still poorly understood. Recent data implicates systemic and paracrine factors secreted from adipose tissue during the obese state, promoting cancer development and progression. Here, we focus on the obesity-associated adipose tissue remodeling that may not only lead to metabolic complications, but also to a permissive pro-tumorigenic environment. Particular attention is given to the local pro-tumorigenic effects derived from adipocytes that present an important part of the tumor microenvironment of at least some cancers, in an attempt to describe the nature of the major players of the adipocyte-cancer cell crosstalk that dictates to a large extent tumor progression.
AB - The prevalence of obesity has increased dramatically in recent decades, reaching epidemic proportions. It is becoming clear that obesity is associated not only with type 2 diabetes mellitus and cardiovascular disease, but also with multiple types of cancer. Obesity is characterized by impaired adipose tissue function, leading to adipocyte hypertrophy, inflammation, hypoxia and induced angiogenesis, extracellular matrix remodeling and fibrosis as well as additional stress responses. While epidemiological data indicate that obesity is a well-established risk factor for certain malignancies, the molecular mechanisms underlying the link between obesity and cancer are still poorly understood. Recent data implicates systemic and paracrine factors secreted from adipose tissue during the obese state, promoting cancer development and progression. Here, we focus on the obesity-associated adipose tissue remodeling that may not only lead to metabolic complications, but also to a permissive pro-tumorigenic environment. Particular attention is given to the local pro-tumorigenic effects derived from adipocytes that present an important part of the tumor microenvironment of at least some cancers, in an attempt to describe the nature of the major players of the adipocyte-cancer cell crosstalk that dictates to a large extent tumor progression.
KW - Adipocyte
KW - Cancer metabolism
KW - Obesity
KW - Stromal compartment
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UR - http://www.scopus.com/inward/citedby.url?scp=84875227258&partnerID=8YFLogxK
U2 - 10.1016/j.pharmthera.2013.01.008
DO - 10.1016/j.pharmthera.2013.01.008
M3 - Article
C2 - 23353703
AN - SCOPUS:84875227258
VL - 138
SP - 197
EP - 210
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
SN - 0163-7258
IS - 2
ER -