Adiponectin preserves metabolic fitness during aging

Na Li, Shangang Zhao, Zhuzhen Zhang, Yi Zhu, Christy M. Gliniak, Lavanya Vishvanath, Yu A. An, May Yun Wang, Yingfeng Deng, Qingzhang Zhu, Bo Shan, Amber Sherwood, Toshiharu Onodera, Orhan K. Oz, Ruth Gordillo, Rana K. Gupta, Ming Liu, Tamas L. Horvath, Vishwa Deep Dixit, Philipp E. Scherer

Research output: Contribution to journalArticlepeer-review

Abstract

Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced agerelated tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.

Original languageEnglish (US)
Article numbere65108
JournaleLife
Volume10
DOIs
StatePublished - 2021

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Adiponectin preserves metabolic fitness during aging'. Together they form a unique fingerprint.

Cite this