Adipose-derived resistin and gut-derived resistin-like molecule-β selectively impair insulin action on glucose production

Michael W. Rajala, Silvana Obici, Philipp E. Scherer, Luciano Rossetti

Research output: Contribution to journalArticle

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The adipose-derived hormone resistin is postulated to link obesity to insulin resistance and diabetes. Here, the infusion of either resistin or the resistin-like molecule-β (RELMβ) rapidly induced severe hepatic but not peripheral insulin resistance. In the presence of physiologic hyperinsulinemia, the infusion of purified recombinant resistin, increasing circulating resistin levels by approximately twofold to 15-fold, inhibited glucose metabolism such that lower rates of glucose infusion were required to maintain the plasma glucose concentration at basal levels. The effects of resistin and RELMβ on in vivo insulin action were completely accounted for by a marked increase in the rate of glucose production. These results support the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalJournal of Clinical Investigation
Issue number2
StatePublished - Jan 2003


ASJC Scopus subject areas

  • Medicine(all)

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