Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes

Fang Chi Hsu, Mingxia Yuan, Donald W. Bowden, Jianzhao Xu, S. Carrie Smith, Lynne E. Wagenknecht, Carl D. Langefeld, Jasmin Divers, Thomas C. Register, J. Jeffrey Carr, Jeff D. Williamson, Kaycee M. Sink, Joseph A Maldjian, Barry I. Freedman

Research output: Contribution to journalArticle

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Abstract

Aims To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D). Methods This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertension, statins, cardiovascular disease, MRI scanner (MRI outcomes only), and time between scans; some neuroimaging measures were additionally adjusted for intracranial volume. Results Participants were 59.9% female with mean (SD) age 57.7(9.3) years, diabetes duration 9.6(6.8) years, and HbA1c 7.8(1.9)%. In AAs, inverse associations were detected between hippocampal GMV and both BMI (β [95% CI] − 0.18 [− 0.30, − 0.07], P = 0.0018) and WC (− 0.23 [− 0.35, − 0.12], P = 0.0001). In the full bi-ethnic sample, inverse associations were detected between hippocampal WMV and WC (P ≤ 0.0001). Positive relationships were observed between BMI (P = 0.0007) and WC (P < 0.0001) with depression in EAs. Conclusions In patients with T2D, adiposity is inversely associated with hippocampal gray and white matter volumes.

Original languageEnglish (US)
Pages (from-to)1506-1512
Number of pages7
JournalJournal of Diabetes and its Complications
Volume30
Issue number8
DOIs
StatePublished - Nov 1 2016

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Adiposity
Waist Circumference
African Americans
Type 2 Diabetes Mellitus
Body Mass Index
Depression
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cone-Beam Computed Tomography
Sex Education
Intra-Abdominal Fat
Subcutaneous Fat
Neuroimaging
Cardiovascular Diseases
Smoking
Magnetic Resonance Imaging
Hypertension
White Matter
Gray Matter

Keywords

  • Adiposity
  • African American
  • Brain
  • Cognition
  • Hippocampus
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes. / Hsu, Fang Chi; Yuan, Mingxia; Bowden, Donald W.; Xu, Jianzhao; Smith, S. Carrie; Wagenknecht, Lynne E.; Langefeld, Carl D.; Divers, Jasmin; Register, Thomas C.; Carr, J. Jeffrey; Williamson, Jeff D.; Sink, Kaycee M.; Maldjian, Joseph A; Freedman, Barry I.

In: Journal of Diabetes and its Complications, Vol. 30, No. 8, 01.11.2016, p. 1506-1512.

Research output: Contribution to journalArticle

Hsu, FC, Yuan, M, Bowden, DW, Xu, J, Smith, SC, Wagenknecht, LE, Langefeld, CD, Divers, J, Register, TC, Carr, JJ, Williamson, JD, Sink, KM, Maldjian, JA & Freedman, BI 2016, 'Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes', Journal of Diabetes and its Complications, vol. 30, no. 8, pp. 1506-1512. https://doi.org/10.1016/j.jdiacomp.2016.08.012
Hsu, Fang Chi ; Yuan, Mingxia ; Bowden, Donald W. ; Xu, Jianzhao ; Smith, S. Carrie ; Wagenknecht, Lynne E. ; Langefeld, Carl D. ; Divers, Jasmin ; Register, Thomas C. ; Carr, J. Jeffrey ; Williamson, Jeff D. ; Sink, Kaycee M. ; Maldjian, Joseph A ; Freedman, Barry I. / Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes. In: Journal of Diabetes and its Complications. 2016 ; Vol. 30, No. 8. pp. 1506-1512.
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abstract = "Aims To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D). Methods This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertension, statins, cardiovascular disease, MRI scanner (MRI outcomes only), and time between scans; some neuroimaging measures were additionally adjusted for intracranial volume. Results Participants were 59.9{\%} female with mean (SD) age 57.7(9.3) years, diabetes duration 9.6(6.8) years, and HbA1c 7.8(1.9){\%}. In AAs, inverse associations were detected between hippocampal GMV and both BMI (β [95{\%} CI] − 0.18 [− 0.30, − 0.07], P = 0.0018) and WC (− 0.23 [− 0.35, − 0.12], P = 0.0001). In the full bi-ethnic sample, inverse associations were detected between hippocampal WMV and WC (P ≤ 0.0001). Positive relationships were observed between BMI (P = 0.0007) and WC (P < 0.0001) with depression in EAs. Conclusions In patients with T2D, adiposity is inversely associated with hippocampal gray and white matter volumes.",
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T1 - Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes

AU - Hsu, Fang Chi

AU - Yuan, Mingxia

AU - Bowden, Donald W.

AU - Xu, Jianzhao

AU - Smith, S. Carrie

AU - Wagenknecht, Lynne E.

AU - Langefeld, Carl D.

AU - Divers, Jasmin

AU - Register, Thomas C.

AU - Carr, J. Jeffrey

AU - Williamson, Jeff D.

AU - Sink, Kaycee M.

AU - Maldjian, Joseph A

AU - Freedman, Barry I.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Aims To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D). Methods This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertension, statins, cardiovascular disease, MRI scanner (MRI outcomes only), and time between scans; some neuroimaging measures were additionally adjusted for intracranial volume. Results Participants were 59.9% female with mean (SD) age 57.7(9.3) years, diabetes duration 9.6(6.8) years, and HbA1c 7.8(1.9)%. In AAs, inverse associations were detected between hippocampal GMV and both BMI (β [95% CI] − 0.18 [− 0.30, − 0.07], P = 0.0018) and WC (− 0.23 [− 0.35, − 0.12], P = 0.0001). In the full bi-ethnic sample, inverse associations were detected between hippocampal WMV and WC (P ≤ 0.0001). Positive relationships were observed between BMI (P = 0.0007) and WC (P < 0.0001) with depression in EAs. Conclusions In patients with T2D, adiposity is inversely associated with hippocampal gray and white matter volumes.

AB - Aims To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D). Methods This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertension, statins, cardiovascular disease, MRI scanner (MRI outcomes only), and time between scans; some neuroimaging measures were additionally adjusted for intracranial volume. Results Participants were 59.9% female with mean (SD) age 57.7(9.3) years, diabetes duration 9.6(6.8) years, and HbA1c 7.8(1.9)%. In AAs, inverse associations were detected between hippocampal GMV and both BMI (β [95% CI] − 0.18 [− 0.30, − 0.07], P = 0.0018) and WC (− 0.23 [− 0.35, − 0.12], P = 0.0001). In the full bi-ethnic sample, inverse associations were detected between hippocampal WMV and WC (P ≤ 0.0001). Positive relationships were observed between BMI (P = 0.0007) and WC (P < 0.0001) with depression in EAs. Conclusions In patients with T2D, adiposity is inversely associated with hippocampal gray and white matter volumes.

KW - Adiposity

KW - African American

KW - Brain

KW - Cognition

KW - Hippocampus

KW - Type 2 diabetes

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