Adjutant-enhanced antibody responses in the absence of toll-like receptor signaling

Amanda L. Gavin, Kasper Hoebe, Bao Duong, Takayuki Ota, Christopher Martin, Bruce Beutler, Davrid Nemazee

Research output: Contribution to journalArticle

430 Citations (Scopus)

Abstract

Innate immune signals mediated by Toll-like receptors (TLRs) have been thought to contribute considerably to the antibody-enhancing effects of vaccine adjuvants. However, we report here that mice deficient in the critical signaling components for TLR mount robust antibody responses to T cell-dependent antigen given in four typical adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant, and monophosphoryl-lipid A/trehalose dicorynomycolate adjuvant. We conclude that TLR signaling does not account for the action of classical adjuvants and does not fully explain the action of a strong adjuvant containing a TLR ligand. This may have important implications in the use and development of vaccine adjuvants.

Original languageEnglish (US)
Pages (from-to)1936-1938
Number of pages3
JournalScience
Volume314
Issue number5807
DOIs
StatePublished - Dec 2006

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Toll-Like Receptors
Antibody Formation
Vaccines
Blocking Antibodies
Freund's Adjuvant
Ligands
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • General

Cite this

Gavin, A. L., Hoebe, K., Duong, B., Ota, T., Martin, C., Beutler, B., & Nemazee, D. (2006). Adjutant-enhanced antibody responses in the absence of toll-like receptor signaling. Science, 314(5807), 1936-1938. https://doi.org/10.1126/science.1135299

Adjutant-enhanced antibody responses in the absence of toll-like receptor signaling. / Gavin, Amanda L.; Hoebe, Kasper; Duong, Bao; Ota, Takayuki; Martin, Christopher; Beutler, Bruce; Nemazee, Davrid.

In: Science, Vol. 314, No. 5807, 12.2006, p. 1936-1938.

Research output: Contribution to journalArticle

Gavin, AL, Hoebe, K, Duong, B, Ota, T, Martin, C, Beutler, B & Nemazee, D 2006, 'Adjutant-enhanced antibody responses in the absence of toll-like receptor signaling', Science, vol. 314, no. 5807, pp. 1936-1938. https://doi.org/10.1126/science.1135299
Gavin, Amanda L. ; Hoebe, Kasper ; Duong, Bao ; Ota, Takayuki ; Martin, Christopher ; Beutler, Bruce ; Nemazee, Davrid. / Adjutant-enhanced antibody responses in the absence of toll-like receptor signaling. In: Science. 2006 ; Vol. 314, No. 5807. pp. 1936-1938.
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