Adjutant-enhanced antibody responses in the absence of toll-like receptor signaling

Amanda L. Gavin, Kasper Hoebe, Bao Duong, Takayuki Ota, Christopher Martin, Bruce Beutler, Davrid Nemazee

Research output: Contribution to journalArticlepeer-review

466 Scopus citations

Abstract

Innate immune signals mediated by Toll-like receptors (TLRs) have been thought to contribute considerably to the antibody-enhancing effects of vaccine adjuvants. However, we report here that mice deficient in the critical signaling components for TLR mount robust antibody responses to T cell-dependent antigen given in four typical adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant, and monophosphoryl-lipid A/trehalose dicorynomycolate adjuvant. We conclude that TLR signaling does not account for the action of classical adjuvants and does not fully explain the action of a strong adjuvant containing a TLR ligand. This may have important implications in the use and development of vaccine adjuvants.

Original languageEnglish (US)
Pages (from-to)1936-1938
Number of pages3
JournalScience
Volume314
Issue number5807
DOIs
StatePublished - Dec 2006

ASJC Scopus subject areas

  • General

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