Administration of 5α-androstane-3α,17β-diol to female tammar wallaby pouch young causes development of a mature prostate and male urethra

Michael W. Leihy, Geoffrey Shaw, Marilyn B. Renfree, Jean D. Wilson

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Secretion of 5α-androstane-3α,17β-diol (5α-adiol) by the testes of the tammar wallaby is responsible for initiation of prostatic development after d 20 in male pouch young. To ascertain the role of this hormone in the subsequent growth and differentiation of the prostate and in the development of the male phallus, 5α-adiol was administered to tammar female pouch young in two regimens. Administration of the hormone by mouth (8 μg/g body weight·wk) between d 70 and 150 of pouch life caused prostate development equivalent to that in d 150 males and promoted growth and differentiation of the penis, but not masculinization of the urethra. Treatment with a small dose of 5α-adiol enanthate (1 μg/g body weight·wk) from d 20-150 produced similar results. However, administration of larger doses of 5α-adiol enanthate (10 or 100 μg/g body weight·wk) from d 20-150 caused supraphysiological growth of the prostate, development of a male-type urethra, and penile growth. These results indicate that prostatic development and penile growth can be initiated over a wide time period, but that formation of a male urethra requires androgen action before d 70, when male penile differentiation begins. This further strengthens the hypothesis that 5α-adiol is the circulating androgen responsible in this species for virilization during development.

Original languageEnglish (US)
Pages (from-to)2643-2651
Number of pages9
JournalEndocrinology
Volume143
Issue number7
DOIs
StatePublished - 2002

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Androstane-3,17-diol
Macropodidae
Urethra
Prostate
Heptanoates
Growth and Development
Androgens
Growth
Hormones
Virilism
Penis
Mouth
Testis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Administration of 5α-androstane-3α,17β-diol to female tammar wallaby pouch young causes development of a mature prostate and male urethra. / Leihy, Michael W.; Shaw, Geoffrey; Renfree, Marilyn B.; Wilson, Jean D.

In: Endocrinology, Vol. 143, No. 7, 2002, p. 2643-2651.

Research output: Contribution to journalArticle

Leihy, Michael W. ; Shaw, Geoffrey ; Renfree, Marilyn B. ; Wilson, Jean D. / Administration of 5α-androstane-3α,17β-diol to female tammar wallaby pouch young causes development of a mature prostate and male urethra. In: Endocrinology. 2002 ; Vol. 143, No. 7. pp. 2643-2651.
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