TY - JOUR
T1 - Adrenergic receptors in premenstrual dysphoric disorder
T2 - I. Platelet α2 receptors: G(i) protein coupling, phase of menstrual cycle, and prediction of luteal phase symptom severity
AU - Gurguis, George N M
AU - Yonkers, Kimberly A.
AU - Phan, Stephanie P.
AU - Blakeley, Jaishri E.
AU - Williams, Anita
AU - Rush, A. John
N1 - Funding Information:
This study was supported in part by a Research Advisory Group grant from the Department of Veterans Affairs to GNMG and a NARSAD Young Investigator Award to KAY.
PY - 1998/10/1
Y1 - 1998/10/1
N2 - Background: Abnormal α2-adrenergic receptor (AR) function is implicated in anxiety and depressive disorders. Premenstrual dysphoric disorder (PMDD) is characterized by anxiety and depressive symptoms, which may be associated with changes in α2AR function. Previous studies on α2AR function during phases of the menstrual cycle in controls and PMDD patients are inconsistent. Methods: α2AR function was examined in 16 PMDD patients and 15 controls during the follicular phase, and in 10 PMDD patients during late luteal phase. Antagonist-measured maximum binding capacity, agonist- measured receptor density in high- and low-conformational states, and agonist affinity to both states were measured. Coupling efficiency to G(i) protein was estimated. Results: There were no significant differences in coupling efficiency. PMDD patients had significantly low antagonist affinity; there were no differences in other binding parameters. There were no changes in α2AR binding parameters between phases of menstrual cycle in PMDD women. α2AR density and symptom severity were inversely related during the follicular phase in controls and patients. During luteal phase, α2AR density correlated positively with symptom severity in patients. High follicular α2AR density predicted more severe luteal symptoms in PMDD patients. Conclusions: These findings are discussed in view of the molecular biology of α2AR, and their role in PMDD, anxiety, and depressive disorders.
AB - Background: Abnormal α2-adrenergic receptor (AR) function is implicated in anxiety and depressive disorders. Premenstrual dysphoric disorder (PMDD) is characterized by anxiety and depressive symptoms, which may be associated with changes in α2AR function. Previous studies on α2AR function during phases of the menstrual cycle in controls and PMDD patients are inconsistent. Methods: α2AR function was examined in 16 PMDD patients and 15 controls during the follicular phase, and in 10 PMDD patients during late luteal phase. Antagonist-measured maximum binding capacity, agonist- measured receptor density in high- and low-conformational states, and agonist affinity to both states were measured. Coupling efficiency to G(i) protein was estimated. Results: There were no significant differences in coupling efficiency. PMDD patients had significantly low antagonist affinity; there were no differences in other binding parameters. There were no changes in α2AR binding parameters between phases of menstrual cycle in PMDD women. α2AR density and symptom severity were inversely related during the follicular phase in controls and patients. During luteal phase, α2AR density correlated positively with symptom severity in patients. High follicular α2AR density predicted more severe luteal symptoms in PMDD patients. Conclusions: These findings are discussed in view of the molecular biology of α2AR, and their role in PMDD, anxiety, and depressive disorders.
KW - Alpha-adrenergic receptors
KW - Anxiety
KW - Coupling
KW - Depression
KW - G protein
KW - Premenstrual syndrome
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U2 - 10.1016/S0006-3223(98)00097-3
DO - 10.1016/S0006-3223(98)00097-3
M3 - Article
C2 - 9787884
AN - SCOPUS:18744420345
SN - 0006-3223
VL - 44
SP - 600
EP - 609
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 7
ER -