Affective Neural Circuitry During Facial Emotion Processing in Pediatric Bipolar Disorder

Mani N. Pavuluri, Megan Marlow O'Connor, Erin Harral, John A. Sweeney

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

Background: Facial emotions are central to human interaction. Identifying pathophysiology in affect processing circuitry that supports the ability to assess facial emotions might facilitate understanding of affect regulation in pediatric bipolar disorder. Methods: Ten euthymic, unmedicated pediatric bipolar patients and 10 healthy control subjects matched for age, gender, race, socioeconomic status, and IQ were scanned with functional magnetic resonance imaging. Angry, happy, and neutral faces were presented in 30-sec blocks, with a 20-sec rest period between blocks. Subjects were asked to press a button when each face appeared, to ensure that attention was maintained on-task. Results: In bipolar patients, in response to both angry and happy faces relative to neutral faces, we observed reduced activation of right rostral ventrolateral prefrontal cortex together with increased activity in right pregenual anterior cingulate, amygdala, and paralimbic cortex. Bipolar patients also showed reduced activation of visual areas in occipital cortex together with greater activation in higher-order visual perceptual areas, including superior temporal sulcus and fusiform gyrus with angry faces and posterior parietal cortex with happy faces. Conclusions: Findings document a disturbance in affective neurocircuitry in pediatric bipolar disorder. Reduced activation in ventrolateral prefrontal cortex might reflect diminished top-down control that leads to the observed exaggerated activation in amygdala and paralimbic areas. Changes in occipital areas might represent an effort to gate sensory input when affective responses to the faces could not be successfully modulated. Disturbances in affect processing circuitry could contribute to emotional dysregulation and social cognitive difficulties in bipolar youth.

Original languageEnglish (US)
Pages (from-to)158-167
Number of pages10
JournalBiological Psychiatry
Volume62
Issue number2
DOIs
StatePublished - Jul 15 2007

Fingerprint

Bipolar Disorder
Emotions
Pediatrics
Temporal Lobe
Amygdala
Prefrontal Cortex
Occipital Lobe
Parietal Lobe
Aptitude
Gyrus Cinguli
Social Class
Healthy Volunteers
Magnetic Resonance Imaging

Keywords

  • Adolescent
  • affect
  • bipolar disorder
  • cognition
  • functional magnetic resonance imaging (fMRI)
  • prefrontal cortex

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Affective Neural Circuitry During Facial Emotion Processing in Pediatric Bipolar Disorder. / Pavuluri, Mani N.; O'Connor, Megan Marlow; Harral, Erin; Sweeney, John A.

In: Biological Psychiatry, Vol. 62, No. 2, 15.07.2007, p. 158-167.

Research output: Contribution to journalArticle

Pavuluri, Mani N. ; O'Connor, Megan Marlow ; Harral, Erin ; Sweeney, John A. / Affective Neural Circuitry During Facial Emotion Processing in Pediatric Bipolar Disorder. In: Biological Psychiatry. 2007 ; Vol. 62, No. 2. pp. 158-167.
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