Aggressive fUS-mutant motor neuron disease without profound spinal cord pathology

Yan Chen Wongworawat, Yin Allison Liu, Ravi Raghavan, Charles L. White, Robin Dietz, Craig Zuppan, Jeffrey Rosenfeld

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A 29-year-old man presented with rapidly progressive severe neck weakness, asymmetrical bilateral upper extremity weakness, bulbar dysfunction, profound muscle wasting, and weight loss. Within 1 year, his speech became unintelligible, he became gastrostomy- and tracheostomy/ventilator-dependent, and wheelchair bound. Electrophysiology suggested motor neuron disease. Whole exome sequencing revealed a heterozygous pathogenic variant in the fused in sarcoma gene (FUS), c.1574C>T,p. R525L, consistent with autosomal dominant amyotrophic lateral sclerosis. Autopsy revealed extensive denervation atrophy of skeletal musculature. Surprisingly, there was only minimal patchy depletion of motor neurons within the cervico-thoracic spinal cord anterior horn cells, and the tracts were largely preserved. TDP-43 inclusions were absent. Abnormal expression of FUS mutation product (cytoplasmic inclusions) was demonstrated by immunohistochemistry within anterior horn motor neurons. The most prominent finding was a disparity between profound neck weakness and relatively low-grade anterior horn cell loss or tract degeneration in the cervico-thoracic cord.

Original languageEnglish (US)
Pages (from-to)365-369
Number of pages5
JournalJournal of neuropathology and experimental neurology
Issue number4
StatePublished - Apr 1 2020


  • Amyotrophic lateral sclerosis (ALS)
  • Cytoplasmic inclusions
  • Fused in sarcoma gene (FUS)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Aggressive fUS-mutant motor neuron disease without profound spinal cord pathology'. Together they form a unique fingerprint.

Cite this