Aging and arterial blood pressure variability during orthostatic challenge

Xiangrong Shi, Guoyuan Huang, Scott A. Smith, Rong Zhang, Kevin J. Formes

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: It has been demonstrated that a decrease in vagal cardiac function compromises arterial blood pressure (ABP) stability during orthostatic challenge. Augmentations in low-frequency (LF) ABP oscillations are indicative of this change in autonomic hemodynamic control. Aging is associated with diminished arterial baroreflex sensitivity and vagal cardiac dysfunction. However, the effect of aging on the stability of ABP during an orthostatic challenge remains to be elucidated. Objective: The purpose of this study was to investigate ABP stability with aging during central hypovolemia induced by lower-body negative pressure (LBNP). Methods: Graded LBNP up to -40 mm Hg was applied in 16 older (65 ± 3 years of age) and 16 younger (25 ± 3 years of age) healthy adults. ABP variability was analyzed by fast Fourier transform. LF spectral density (0.04-0.15 Hz) was extracted to provide an index of vasomotor responsiveness. Results: Both LF systolic blood pressure (SBP) variability and diastolic blood pressure variability were augmented with LBNP. The rate of increase in LF SBP variability was augmented significantly greater in older as compared with younger subjects (p = 0.049). In addition, LF SBP variability was inversely correlated with decreases in pulse pressure in both age groups (r = -0.84, p = 0.01). The magnitude of the decreases in SBP and pulse pressure during LBNP was significantly affected by age, with the largest changes occurring in older subjects. The altered ABP response that manifested in older individuals was associated with a significant diminution in the reflex tachycardiac response elicited by LBNP. Conclusions: Induction of central hypovolemia via graded LBNP augments LF ABP variability. This increased ABP variability is significantly greater in older individuals. Our data suggest that aging is associated with ABP instability during orthostatic challenge.

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalGerontology
Volume49
Issue number5
DOIs
StatePublished - 2003

Fingerprint

Arterial Pressure
Lower Body Negative Pressure
Blood Pressure
Hypovolemia
Baroreflex
Fourier Analysis
Reflex
Age Groups
Hemodynamics

Keywords

  • Arterial baroreceptor reflex
  • Lower-body negative pressure
  • Power spectral analysis

ASJC Scopus subject areas

  • Aging

Cite this

Aging and arterial blood pressure variability during orthostatic challenge. / Shi, Xiangrong; Huang, Guoyuan; Smith, Scott A.; Zhang, Rong; Formes, Kevin J.

In: Gerontology, Vol. 49, No. 5, 2003, p. 279-286.

Research output: Contribution to journalArticle

Shi, Xiangrong ; Huang, Guoyuan ; Smith, Scott A. ; Zhang, Rong ; Formes, Kevin J. / Aging and arterial blood pressure variability during orthostatic challenge. In: Gerontology. 2003 ; Vol. 49, No. 5. pp. 279-286.
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N2 - Background: It has been demonstrated that a decrease in vagal cardiac function compromises arterial blood pressure (ABP) stability during orthostatic challenge. Augmentations in low-frequency (LF) ABP oscillations are indicative of this change in autonomic hemodynamic control. Aging is associated with diminished arterial baroreflex sensitivity and vagal cardiac dysfunction. However, the effect of aging on the stability of ABP during an orthostatic challenge remains to be elucidated. Objective: The purpose of this study was to investigate ABP stability with aging during central hypovolemia induced by lower-body negative pressure (LBNP). Methods: Graded LBNP up to -40 mm Hg was applied in 16 older (65 ± 3 years of age) and 16 younger (25 ± 3 years of age) healthy adults. ABP variability was analyzed by fast Fourier transform. LF spectral density (0.04-0.15 Hz) was extracted to provide an index of vasomotor responsiveness. Results: Both LF systolic blood pressure (SBP) variability and diastolic blood pressure variability were augmented with LBNP. The rate of increase in LF SBP variability was augmented significantly greater in older as compared with younger subjects (p = 0.049). In addition, LF SBP variability was inversely correlated with decreases in pulse pressure in both age groups (r = -0.84, p = 0.01). The magnitude of the decreases in SBP and pulse pressure during LBNP was significantly affected by age, with the largest changes occurring in older subjects. The altered ABP response that manifested in older individuals was associated with a significant diminution in the reflex tachycardiac response elicited by LBNP. Conclusions: Induction of central hypovolemia via graded LBNP augments LF ABP variability. This increased ABP variability is significantly greater in older individuals. Our data suggest that aging is associated with ABP instability during orthostatic challenge.

AB - Background: It has been demonstrated that a decrease in vagal cardiac function compromises arterial blood pressure (ABP) stability during orthostatic challenge. Augmentations in low-frequency (LF) ABP oscillations are indicative of this change in autonomic hemodynamic control. Aging is associated with diminished arterial baroreflex sensitivity and vagal cardiac dysfunction. However, the effect of aging on the stability of ABP during an orthostatic challenge remains to be elucidated. Objective: The purpose of this study was to investigate ABP stability with aging during central hypovolemia induced by lower-body negative pressure (LBNP). Methods: Graded LBNP up to -40 mm Hg was applied in 16 older (65 ± 3 years of age) and 16 younger (25 ± 3 years of age) healthy adults. ABP variability was analyzed by fast Fourier transform. LF spectral density (0.04-0.15 Hz) was extracted to provide an index of vasomotor responsiveness. Results: Both LF systolic blood pressure (SBP) variability and diastolic blood pressure variability were augmented with LBNP. The rate of increase in LF SBP variability was augmented significantly greater in older as compared with younger subjects (p = 0.049). In addition, LF SBP variability was inversely correlated with decreases in pulse pressure in both age groups (r = -0.84, p = 0.01). The magnitude of the decreases in SBP and pulse pressure during LBNP was significantly affected by age, with the largest changes occurring in older subjects. The altered ABP response that manifested in older individuals was associated with a significant diminution in the reflex tachycardiac response elicited by LBNP. Conclusions: Induction of central hypovolemia via graded LBNP augments LF ABP variability. This increased ABP variability is significantly greater in older individuals. Our data suggest that aging is associated with ABP instability during orthostatic challenge.

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