Allopurinol preserves cerebral energy metabolism during perinatal hypoxia-ischemia: A 31P NMR study in unanesthetized immature rats

Gerald D. Williams, Charles Palmer, Daniel F. Heitjan, Michael B. Smith

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The effects of high dose allopurinol (ALLOP) pretreatment on the cerebral energy metabolism of unanesthetized 7-day-postnatal rats during exposure to 3 h of cerebral hypoxia-ischemia were serially quantitated using non-invasive 31P NMR spectroscopy. Adenosine triphosphate, integrated over the last 2 h of hypoxia and expressed as a fraction of baseline, was 0.73±0.16 with ALLOP pretreatment (200 mg/kg s.c.) compared to 0.52±0.05 for saline pretreatment (P=0.001). Inorganic phosphate/phosphocreatine (Pi/PCr), integrated over the same time interval, was 2.63±1.23 relative to baseline with ALLOP versus 5.13±1.45 for saline-treated pups (P<0.0005). We suggest that the neuroprotection achieved with high dose ALLOP pretreatment may be attributed in part to preservation of energy metabolites.

Original languageEnglish (US)
Pages (from-to)103-106
Number of pages4
JournalNeuroscience Letters
Volume144
Issue number1-2
DOIs
StatePublished - Sep 14 1992

Keywords

  • Adenosine triphosphate
  • Allopurinol
  • Hypoxia-ischemia
  • Immature animal
  • Neuroprotective
  • Nuclear magnetic resonance
  • Rat brain
  • Xanthine oxidase

ASJC Scopus subject areas

  • Neuroscience(all)

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