Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass

Aki Uchida, Juliet F. Zechner, Bharath K. Mani, Won mee Park, Vincent Aguirre, Jeffrey M. Zigman

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB). We hypothesized that circulating ghrelin levels were altered in obesity and after weight loss through changes in ghrelin cell responsiveness to physiological cues. We confirmed lower ghrelin levels in DIO mice and demonstrated elevated ghrelin levels in mice 6 weeks post-RYGB. In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion - glucose and norepinephrine. In DIO mice, increases in ghrelin cell density within both the stomach and duodenum and in somatostatin-immunoreactive D cell density in the duodenum were observed. Our findings provide new insights into the regulation of ghrelin secretion and its relation to circulating ghrelin within the contexts of obesity and weight loss.

Original languageEnglish (US)
Pages (from-to)717-730
Number of pages14
JournalMolecular Metabolism
Volume3
Issue number7
DOIs
StatePublished - Oct 1 2014

Keywords

  • Ghrelin secretion
  • Glucose
  • Norepinephrine
  • Obesity
  • Roux-en-Y gastric bypass
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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