Ambient pollution and blood pressure in cardiac rehabilitation patients

Antonella Zanobetti, Marina Jacobson Canner, Peter H. Stone, Joel Schwartz, David Sher, Elizabeth Eagan-Bengston, Karen A. Gates, L. Howard Hartley, Helen Suh, Diane R. Gold

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

Background - Multiple studies have demonstrated a consistent association between ambient particulate air pollution and increased risk of hospital admissions and deaths for cardiovascular causes. We investigated the associations between fine particulate pollution (PM2.5) and blood pressure during 631 repeated visits for cardiac rehabilitation in 62 Boston residents with cardiovascular disease. Methods and Results - Blood pressure, cardiac risk factor, and exercise data were abstracted from records of rehabilitation visits between 1999 and 2001. We applied mixed-effect models, controlling for body mass index, age, gender, number of visits, hour of day, and weather variables. For an increase from the 10th to the 90th percentile in mean PM2.5 level during the 5 days before the visit (10.5 μg/m 3), there was a 2.8-mm Hg (95% CI, 0.1 to 5.5) increase in resting systolic, a 2.7-mm Hg (95% CI, 1.2 to 4.3) increase in resting diastolic, and a 2.7-mm Hg (95% CI, 1.0 to 4.5) increase in resting mean arterial blood pressure. The mean PM2.5 level during the 2 preceding days (13.9 μg/m 3) was associated with a 7.0-mm Hg (95% CI, 2.3 to 12.1) increase in diastolic and a 4.7-mm Hg (95% CI, 0.5 to 9.1) increase in mean arterial blood pressure during exercise in persons with resting heart rate ≥70 bpm, but it was not associated with an increase in blood pressure during exercise in persons with heart rate <70 bpm. Conclusions - In patients with preexisting cardiac disease, particle pollution may contribute to increased risk of cardiac morbidity and mortality through short-term increases in systemic arterial vascular narrowing, as manifested by increased peripheral blood pressure.

Original languageEnglish (US)
Pages (from-to)2184-2189
Number of pages6
JournalCirculation
Volume110
Issue number15
DOIs
StatePublished - Oct 12 2004

Fingerprint

Arterial Pressure
Blood Pressure
Exercise
Heart Rate
Preexisting Condition Coverage
Air Pollution
Weather
Blood Vessels
Cause of Death
Heart Diseases
Body Mass Index
Cardiovascular Diseases
Rehabilitation
Morbidity
Mortality
Cardiac Rehabilitation

Keywords

  • Air pollution
  • Blood pressure
  • Cardiovascular diseases
  • Environmental exposure
  • Epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Zanobetti, A., Canner, M. J., Stone, P. H., Schwartz, J., Sher, D., Eagan-Bengston, E., ... Gold, D. R. (2004). Ambient pollution and blood pressure in cardiac rehabilitation patients. Circulation, 110(15), 2184-2189. https://doi.org/10.1161/01.CIR.0000143831.33243.D8

Ambient pollution and blood pressure in cardiac rehabilitation patients. / Zanobetti, Antonella; Canner, Marina Jacobson; Stone, Peter H.; Schwartz, Joel; Sher, David; Eagan-Bengston, Elizabeth; Gates, Karen A.; Hartley, L. Howard; Suh, Helen; Gold, Diane R.

In: Circulation, Vol. 110, No. 15, 12.10.2004, p. 2184-2189.

Research output: Contribution to journalArticle

Zanobetti, A, Canner, MJ, Stone, PH, Schwartz, J, Sher, D, Eagan-Bengston, E, Gates, KA, Hartley, LH, Suh, H & Gold, DR 2004, 'Ambient pollution and blood pressure in cardiac rehabilitation patients', Circulation, vol. 110, no. 15, pp. 2184-2189. https://doi.org/10.1161/01.CIR.0000143831.33243.D8
Zanobetti A, Canner MJ, Stone PH, Schwartz J, Sher D, Eagan-Bengston E et al. Ambient pollution and blood pressure in cardiac rehabilitation patients. Circulation. 2004 Oct 12;110(15):2184-2189. https://doi.org/10.1161/01.CIR.0000143831.33243.D8
Zanobetti, Antonella ; Canner, Marina Jacobson ; Stone, Peter H. ; Schwartz, Joel ; Sher, David ; Eagan-Bengston, Elizabeth ; Gates, Karen A. ; Hartley, L. Howard ; Suh, Helen ; Gold, Diane R. / Ambient pollution and blood pressure in cardiac rehabilitation patients. In: Circulation. 2004 ; Vol. 110, No. 15. pp. 2184-2189.
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abstract = "Background - Multiple studies have demonstrated a consistent association between ambient particulate air pollution and increased risk of hospital admissions and deaths for cardiovascular causes. We investigated the associations between fine particulate pollution (PM2.5) and blood pressure during 631 repeated visits for cardiac rehabilitation in 62 Boston residents with cardiovascular disease. Methods and Results - Blood pressure, cardiac risk factor, and exercise data were abstracted from records of rehabilitation visits between 1999 and 2001. We applied mixed-effect models, controlling for body mass index, age, gender, number of visits, hour of day, and weather variables. For an increase from the 10th to the 90th percentile in mean PM2.5 level during the 5 days before the visit (10.5 μg/m 3), there was a 2.8-mm Hg (95{\%} CI, 0.1 to 5.5) increase in resting systolic, a 2.7-mm Hg (95{\%} CI, 1.2 to 4.3) increase in resting diastolic, and a 2.7-mm Hg (95{\%} CI, 1.0 to 4.5) increase in resting mean arterial blood pressure. The mean PM2.5 level during the 2 preceding days (13.9 μg/m 3) was associated with a 7.0-mm Hg (95{\%} CI, 2.3 to 12.1) increase in diastolic and a 4.7-mm Hg (95{\%} CI, 0.5 to 9.1) increase in mean arterial blood pressure during exercise in persons with resting heart rate ≥70 bpm, but it was not associated with an increase in blood pressure during exercise in persons with heart rate <70 bpm. Conclusions - In patients with preexisting cardiac disease, particle pollution may contribute to increased risk of cardiac morbidity and mortality through short-term increases in systemic arterial vascular narrowing, as manifested by increased peripheral blood pressure.",
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AU - Eagan-Bengston, Elizabeth

AU - Gates, Karen A.

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N2 - Background - Multiple studies have demonstrated a consistent association between ambient particulate air pollution and increased risk of hospital admissions and deaths for cardiovascular causes. We investigated the associations between fine particulate pollution (PM2.5) and blood pressure during 631 repeated visits for cardiac rehabilitation in 62 Boston residents with cardiovascular disease. Methods and Results - Blood pressure, cardiac risk factor, and exercise data were abstracted from records of rehabilitation visits between 1999 and 2001. We applied mixed-effect models, controlling for body mass index, age, gender, number of visits, hour of day, and weather variables. For an increase from the 10th to the 90th percentile in mean PM2.5 level during the 5 days before the visit (10.5 μg/m 3), there was a 2.8-mm Hg (95% CI, 0.1 to 5.5) increase in resting systolic, a 2.7-mm Hg (95% CI, 1.2 to 4.3) increase in resting diastolic, and a 2.7-mm Hg (95% CI, 1.0 to 4.5) increase in resting mean arterial blood pressure. The mean PM2.5 level during the 2 preceding days (13.9 μg/m 3) was associated with a 7.0-mm Hg (95% CI, 2.3 to 12.1) increase in diastolic and a 4.7-mm Hg (95% CI, 0.5 to 9.1) increase in mean arterial blood pressure during exercise in persons with resting heart rate ≥70 bpm, but it was not associated with an increase in blood pressure during exercise in persons with heart rate <70 bpm. Conclusions - In patients with preexisting cardiac disease, particle pollution may contribute to increased risk of cardiac morbidity and mortality through short-term increases in systemic arterial vascular narrowing, as manifested by increased peripheral blood pressure.

AB - Background - Multiple studies have demonstrated a consistent association between ambient particulate air pollution and increased risk of hospital admissions and deaths for cardiovascular causes. We investigated the associations between fine particulate pollution (PM2.5) and blood pressure during 631 repeated visits for cardiac rehabilitation in 62 Boston residents with cardiovascular disease. Methods and Results - Blood pressure, cardiac risk factor, and exercise data were abstracted from records of rehabilitation visits between 1999 and 2001. We applied mixed-effect models, controlling for body mass index, age, gender, number of visits, hour of day, and weather variables. For an increase from the 10th to the 90th percentile in mean PM2.5 level during the 5 days before the visit (10.5 μg/m 3), there was a 2.8-mm Hg (95% CI, 0.1 to 5.5) increase in resting systolic, a 2.7-mm Hg (95% CI, 1.2 to 4.3) increase in resting diastolic, and a 2.7-mm Hg (95% CI, 1.0 to 4.5) increase in resting mean arterial blood pressure. The mean PM2.5 level during the 2 preceding days (13.9 μg/m 3) was associated with a 7.0-mm Hg (95% CI, 2.3 to 12.1) increase in diastolic and a 4.7-mm Hg (95% CI, 0.5 to 9.1) increase in mean arterial blood pressure during exercise in persons with resting heart rate ≥70 bpm, but it was not associated with an increase in blood pressure during exercise in persons with heart rate <70 bpm. Conclusions - In patients with preexisting cardiac disease, particle pollution may contribute to increased risk of cardiac morbidity and mortality through short-term increases in systemic arterial vascular narrowing, as manifested by increased peripheral blood pressure.

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