Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3

Eric M. Wauson, Elma Zaganjor, Melanie H. Cobb

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Cells require the ability to rapidly detect decreases in concentrations of free amino acids so that homeostatic mechanisms, including autophagy, can be engaged to replenish amino acids. Amino acids are transported into cells where it is generally accepted that they are detected by an intracellular sensor. We now show that the cell surface G protein coupled receptor (GPCR) TAS1R1-TAS1R3 (T1R1-T1R3) can sense extracellular amino acids, activate MTORC1, and inhibit autophagy. This receptor is expressed in most tissues and fasted TAS1R3 -/- mice have increased autophagy in the heart, skeletal muscle and liver.

Original languageEnglish (US)
Pages (from-to)418-419
Number of pages2
JournalAutophagy
Volume9
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Autophagy
G-Protein-Coupled Receptors
Amino Acids
Myocardium
Membrane Proteins
Skeletal Muscle
Liver

Keywords

  • Amino Acids
  • Ampk
  • Autophagy
  • Gpcr
  • Lysosome
  • Mtor
  • T1R1
  • T1R3
  • Ulk

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3. / Wauson, Eric M.; Zaganjor, Elma; Cobb, Melanie H.

In: Autophagy, Vol. 9, No. 3, 03.2013, p. 418-419.

Research output: Contribution to journalArticle

Wauson, Eric M. ; Zaganjor, Elma ; Cobb, Melanie H. / Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3. In: Autophagy. 2013 ; Vol. 9, No. 3. pp. 418-419.
@article{09da8f077fd54b24a5482152778fb305,
title = "Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3",
abstract = "Cells require the ability to rapidly detect decreases in concentrations of free amino acids so that homeostatic mechanisms, including autophagy, can be engaged to replenish amino acids. Amino acids are transported into cells where it is generally accepted that they are detected by an intracellular sensor. We now show that the cell surface G protein coupled receptor (GPCR) TAS1R1-TAS1R3 (T1R1-T1R3) can sense extracellular amino acids, activate MTORC1, and inhibit autophagy. This receptor is expressed in most tissues and fasted TAS1R3 -/- mice have increased autophagy in the heart, skeletal muscle and liver.",
keywords = "Amino Acids, Ampk, Autophagy, Gpcr, Lysosome, Mtor, T1R1, T1R3, Ulk",
author = "Wauson, {Eric M.} and Elma Zaganjor and Cobb, {Melanie H.}",
year = "2013",
month = "3",
doi = "10.4161/auto.22911",
language = "English (US)",
volume = "9",
pages = "418--419",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Landes Bioscience",
number = "3",

}

TY - JOUR

T1 - Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3

AU - Wauson, Eric M.

AU - Zaganjor, Elma

AU - Cobb, Melanie H.

PY - 2013/3

Y1 - 2013/3

N2 - Cells require the ability to rapidly detect decreases in concentrations of free amino acids so that homeostatic mechanisms, including autophagy, can be engaged to replenish amino acids. Amino acids are transported into cells where it is generally accepted that they are detected by an intracellular sensor. We now show that the cell surface G protein coupled receptor (GPCR) TAS1R1-TAS1R3 (T1R1-T1R3) can sense extracellular amino acids, activate MTORC1, and inhibit autophagy. This receptor is expressed in most tissues and fasted TAS1R3 -/- mice have increased autophagy in the heart, skeletal muscle and liver.

AB - Cells require the ability to rapidly detect decreases in concentrations of free amino acids so that homeostatic mechanisms, including autophagy, can be engaged to replenish amino acids. Amino acids are transported into cells where it is generally accepted that they are detected by an intracellular sensor. We now show that the cell surface G protein coupled receptor (GPCR) TAS1R1-TAS1R3 (T1R1-T1R3) can sense extracellular amino acids, activate MTORC1, and inhibit autophagy. This receptor is expressed in most tissues and fasted TAS1R3 -/- mice have increased autophagy in the heart, skeletal muscle and liver.

KW - Amino Acids

KW - Ampk

KW - Autophagy

KW - Gpcr

KW - Lysosome

KW - Mtor

KW - T1R1

KW - T1R3

KW - Ulk

UR - http://www.scopus.com/inward/record.url?scp=84877317364&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877317364&partnerID=8YFLogxK

U2 - 10.4161/auto.22911

DO - 10.4161/auto.22911

M3 - Article

VL - 9

SP - 418

EP - 419

JO - Autophagy

JF - Autophagy

SN - 1554-8627

IS - 3

ER -