AMPylation of rho GTPases subverts multiple host signaling processes

Andrew R. Woolery; Xiaobo Yu; Joshua LaBaer; Kim Orth

doi:10.1074/jbc.M114.601310

AMPylation of rho GTPases subverts multiple host signaling processes

Andrew R. Woolery, Xiaobo Yu, Joshua LaBaer, Kim Orth

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Background: VopS is a bacterial effector that AMPylates Rho GTPases.

Results: AMPylation of Rho GTPases inhibits their interaction with multiple downstream effectors.

Conclusion: VopS conducts a multifaceted host signaling inhibition program by targeting the critical Rho GTPases.

Significance: Broadens the understanding of how switch-1 modification of Rho GTPases affects host responses.

Original language	English (US)
Pages (from-to)	32977-32988
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	47
DOIs	https://doi.org/10.1074/jbc.M114.601310
State	Published - Nov 21 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: VopS is a bacterial effector that AMPylates Rho GTPases.Results: AMPylation of Rho GTPases inhibits their interaction with multiple downstream effectors.Conclusion: VopS conducts a multifaceted host signaling inhibition program by targeting the critical Rho GTPases.Significance: Broadens the understanding of how switch-1 modification of Rho GTPases affects host responses.",

author = "Woolery, {Andrew R.} and Xiaobo Yu and Joshua LaBaer and Kim Orth",

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AB - Background: VopS is a bacterial effector that AMPylates Rho GTPases.Results: AMPylation of Rho GTPases inhibits their interaction with multiple downstream effectors.Conclusion: VopS conducts a multifaceted host signaling inhibition program by targeting the critical Rho GTPases.Significance: Broadens the understanding of how switch-1 modification of Rho GTPases affects host responses.

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AMPylation of rho GTPases subverts multiple host signaling processes

Abstract

ASJC Scopus subject areas

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