Background: VopS is a bacterial effector that AMPylates Rho GTPases.
Results: AMPylation of Rho GTPases inhibits their interaction with multiple downstream effectors.
Conclusion: VopS conducts a multifaceted host signaling inhibition program by targeting the critical Rho GTPases.
Significance: Broadens the understanding of how switch-1 modification of Rho GTPases affects host responses.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology