An adaptive complex independent component analysis to analyze dynamic contrast enhanced-MRI

Hatef Mehrabian, Ian Pang, Rajiv Chopra, Anne L. Martel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Pharmacokinetic (PK) modeling of tumors provides information about perfusion and vascular permeability of tumors. Identifying arterial input function (AIF) is crucial in PK modeling using dynamic contrast enhanced (DCE)-MRI. An adaptive complex independent component analysis method is developed to identify and separate AIF from complex DCE-MRI data. The results are compared with a previously introduced AIF estimation method that applied ICA to magnitude DCE-MRI data. Using simulation and experimental phantom studies it is shown that using both magnitude and phase data (complex) results in a more robust and more accurate AIF measurement algorithm.

Original languageEnglish (US)
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
Pages1052-1055
Number of pages4
DOIs
StatePublished - Aug 15 2012
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: May 2 2012May 5 2012

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
CountrySpain
CityBarcelona
Period5/2/125/5/12

Keywords

  • Adaptive Complex ICA (AC-ICA)
  • Arterial Input Function (AIF)
  • Pharmacokinetic modeling

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Mehrabian, H., Pang, I., Chopra, R., & Martel, A. L. (2012). An adaptive complex independent component analysis to analyze dynamic contrast enhanced-MRI. In 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings (pp. 1052-1055). [6235739] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2012.6235739