An Analysis of Individual Body Fat Depots and Risk of Developing Cancer: Insights From the Dallas Heart Study

Arjun Gupta, Ambarish Pandey, Colby Ayers, Muhammad S Beg, Susan G. Lakoski, Gloria L Vega, Scott M Grundy, David H Johnson, Ian J Neeland

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective To examine the association between specific adipose tissue depots and the risk of incident cancer in the Dallas Heart Study. Patients and Methods Individuals without prevalent cancer in the Dallas Heart Study underwent quantification of adipose depots: visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue, and liver fat by magnetic resonance imaging, and subcutaneous lower-body fat (LBF) by dual-energy X-ray absorptiometry from January 1, 2000, through December 31, 2002, and were observed for the development of cancer for up to 12 years. Multivariable Cox proportional hazards modeling was performed to examine the association between fat depots and cancer. Results Of 2627 participants (median age, 43 years; 69% nonwhite race), 167 (6.4%) developed cancer. The most common primary sites of cancer were the breast (in women) and the prostate (in men). In multivariable models adjusted for age, sex, race, smoking, alcohol use, family history of malignancy, and body mass index, a 1-SD increase in VAT was not associated with increased risk of cancer (hazard ratio [HR], 0.94; 95% CI, 0.77-1.14). In contrast, each 1-SD increase in LBF was associated with a reduced incidence of cancer (HR, 0.69; 95% CI, 0.52-0.92) in the fully adjusted model. Conclusions In this study, adiposity-associated cancer risk was heterogeneous and varied by fat depot: VAT was not independently associated with incident cancer, and LBF seemed to protect against cancer development. Further studies of the adiposity-cancer relationship, including serial assessments, are needed to better elucidate this relationship.

Original languageEnglish (US)
Pages (from-to)536-543
Number of pages8
JournalMayo Clinic Proceedings
Volume92
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Adipose Tissue
Neoplasms
Intra-Abdominal Fat
Fats
Adiposity
Abdominal Subcutaneous Fat
Photon Absorptiometry
Prostate
Body Mass Index
Smoking
Alcohols
Magnetic Resonance Imaging
Breast Neoplasms
Liver
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

An Analysis of Individual Body Fat Depots and Risk of Developing Cancer : Insights From the Dallas Heart Study. / Gupta, Arjun; Pandey, Ambarish; Ayers, Colby; Beg, Muhammad S; Lakoski, Susan G.; Vega, Gloria L; Grundy, Scott M; Johnson, David H; Neeland, Ian J.

In: Mayo Clinic Proceedings, Vol. 92, No. 4, 01.04.2017, p. 536-543.

Research output: Contribution to journalArticle

@article{da630d1133454e61903ae88aba8023dd,
title = "An Analysis of Individual Body Fat Depots and Risk of Developing Cancer: Insights From the Dallas Heart Study",
abstract = "Objective To examine the association between specific adipose tissue depots and the risk of incident cancer in the Dallas Heart Study. Patients and Methods Individuals without prevalent cancer in the Dallas Heart Study underwent quantification of adipose depots: visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue, and liver fat by magnetic resonance imaging, and subcutaneous lower-body fat (LBF) by dual-energy X-ray absorptiometry from January 1, 2000, through December 31, 2002, and were observed for the development of cancer for up to 12 years. Multivariable Cox proportional hazards modeling was performed to examine the association between fat depots and cancer. Results Of 2627 participants (median age, 43 years; 69{\%} nonwhite race), 167 (6.4{\%}) developed cancer. The most common primary sites of cancer were the breast (in women) and the prostate (in men). In multivariable models adjusted for age, sex, race, smoking, alcohol use, family history of malignancy, and body mass index, a 1-SD increase in VAT was not associated with increased risk of cancer (hazard ratio [HR], 0.94; 95{\%} CI, 0.77-1.14). In contrast, each 1-SD increase in LBF was associated with a reduced incidence of cancer (HR, 0.69; 95{\%} CI, 0.52-0.92) in the fully adjusted model. Conclusions In this study, adiposity-associated cancer risk was heterogeneous and varied by fat depot: VAT was not independently associated with incident cancer, and LBF seemed to protect against cancer development. Further studies of the adiposity-cancer relationship, including serial assessments, are needed to better elucidate this relationship.",
author = "Arjun Gupta and Ambarish Pandey and Colby Ayers and Beg, {Muhammad S} and Lakoski, {Susan G.} and Vega, {Gloria L} and Grundy, {Scott M} and Johnson, {David H} and Neeland, {Ian J}",
year = "2017",
month = "4",
day = "1",
doi = "10.1016/j.mayocp.2016.12.023",
language = "English (US)",
volume = "92",
pages = "536--543",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "4",

}

TY - JOUR

T1 - An Analysis of Individual Body Fat Depots and Risk of Developing Cancer

T2 - Insights From the Dallas Heart Study

AU - Gupta, Arjun

AU - Pandey, Ambarish

AU - Ayers, Colby

AU - Beg, Muhammad S

AU - Lakoski, Susan G.

AU - Vega, Gloria L

AU - Grundy, Scott M

AU - Johnson, David H

AU - Neeland, Ian J

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objective To examine the association between specific adipose tissue depots and the risk of incident cancer in the Dallas Heart Study. Patients and Methods Individuals without prevalent cancer in the Dallas Heart Study underwent quantification of adipose depots: visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue, and liver fat by magnetic resonance imaging, and subcutaneous lower-body fat (LBF) by dual-energy X-ray absorptiometry from January 1, 2000, through December 31, 2002, and were observed for the development of cancer for up to 12 years. Multivariable Cox proportional hazards modeling was performed to examine the association between fat depots and cancer. Results Of 2627 participants (median age, 43 years; 69% nonwhite race), 167 (6.4%) developed cancer. The most common primary sites of cancer were the breast (in women) and the prostate (in men). In multivariable models adjusted for age, sex, race, smoking, alcohol use, family history of malignancy, and body mass index, a 1-SD increase in VAT was not associated with increased risk of cancer (hazard ratio [HR], 0.94; 95% CI, 0.77-1.14). In contrast, each 1-SD increase in LBF was associated with a reduced incidence of cancer (HR, 0.69; 95% CI, 0.52-0.92) in the fully adjusted model. Conclusions In this study, adiposity-associated cancer risk was heterogeneous and varied by fat depot: VAT was not independently associated with incident cancer, and LBF seemed to protect against cancer development. Further studies of the adiposity-cancer relationship, including serial assessments, are needed to better elucidate this relationship.

AB - Objective To examine the association between specific adipose tissue depots and the risk of incident cancer in the Dallas Heart Study. Patients and Methods Individuals without prevalent cancer in the Dallas Heart Study underwent quantification of adipose depots: visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue, and liver fat by magnetic resonance imaging, and subcutaneous lower-body fat (LBF) by dual-energy X-ray absorptiometry from January 1, 2000, through December 31, 2002, and were observed for the development of cancer for up to 12 years. Multivariable Cox proportional hazards modeling was performed to examine the association between fat depots and cancer. Results Of 2627 participants (median age, 43 years; 69% nonwhite race), 167 (6.4%) developed cancer. The most common primary sites of cancer were the breast (in women) and the prostate (in men). In multivariable models adjusted for age, sex, race, smoking, alcohol use, family history of malignancy, and body mass index, a 1-SD increase in VAT was not associated with increased risk of cancer (hazard ratio [HR], 0.94; 95% CI, 0.77-1.14). In contrast, each 1-SD increase in LBF was associated with a reduced incidence of cancer (HR, 0.69; 95% CI, 0.52-0.92) in the fully adjusted model. Conclusions In this study, adiposity-associated cancer risk was heterogeneous and varied by fat depot: VAT was not independently associated with incident cancer, and LBF seemed to protect against cancer development. Further studies of the adiposity-cancer relationship, including serial assessments, are needed to better elucidate this relationship.

UR - http://www.scopus.com/inward/record.url?scp=85014763284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014763284&partnerID=8YFLogxK

U2 - 10.1016/j.mayocp.2016.12.023

DO - 10.1016/j.mayocp.2016.12.023

M3 - Article

C2 - 28291590

AN - SCOPUS:85014763284

VL - 92

SP - 536

EP - 543

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 4

ER -