An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines

Su Dong Cho, Yong Dae Park, Jeum Jong Kim, Woo Hong Joo, Motoo Shiro, Lothar Esser, J R Falck, Chuljin Ahn, Dong Soo Shin, Yong Jin Yoon

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A series of fused isoquinoline-pyridazinooxazine chimera were prepared in good overall yield from phenethylamide 1 and 4,5-dichloropyridazin-3-one 2 via Smiles rearrangement and Pictet-Spengler cyclization.

Original languageEnglish (US)
Pages (from-to)3763-3773
Number of pages11
JournalTetrahedron
Volume60
Issue number17
DOIs
StatePublished - Apr 19 2004

Fingerprint

Tetrahydroisoquinolines
Cyclization
isoquinoline

Keywords

  • Pyridazino[4,5-b][1,4]oxazine
  • Tetracyclic isoquinolines

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Cho, S. D., Park, Y. D., Kim, J. J., Joo, W. H., Shiro, M., Esser, L., ... Yoon, Y. J. (2004). An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines. Tetrahedron, 60(17), 3763-3773. https://doi.org/10.1016/j.tet.2004.03.011

An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines. / Cho, Su Dong; Park, Yong Dae; Kim, Jeum Jong; Joo, Woo Hong; Shiro, Motoo; Esser, Lothar; Falck, J R; Ahn, Chuljin; Shin, Dong Soo; Yoon, Yong Jin.

In: Tetrahedron, Vol. 60, No. 17, 19.04.2004, p. 3763-3773.

Research output: Contribution to journalArticle

Cho, SD, Park, YD, Kim, JJ, Joo, WH, Shiro, M, Esser, L, Falck, JR, Ahn, C, Shin, DS & Yoon, YJ 2004, 'An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines', Tetrahedron, vol. 60, no. 17, pp. 3763-3773. https://doi.org/10.1016/j.tet.2004.03.011
Cho SD, Park YD, Kim JJ, Joo WH, Shiro M, Esser L et al. An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines. Tetrahedron. 2004 Apr 19;60(17):3763-3773. https://doi.org/10.1016/j.tet.2004.03.011
Cho, Su Dong ; Park, Yong Dae ; Kim, Jeum Jong ; Joo, Woo Hong ; Shiro, Motoo ; Esser, Lothar ; Falck, J R ; Ahn, Chuljin ; Shin, Dong Soo ; Yoon, Yong Jin. / An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines. In: Tetrahedron. 2004 ; Vol. 60, No. 17. pp. 3763-3773.
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