An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines

Su Dong Cho, Yong Dae Park, Jeum Jong Kim, Woo Hong Joo, Motoo Shiro, Lothar Esser, J R Falck, Chuljin Ahn, Dong Soo Shin, Yong Jin Yoon

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


A series of fused isoquinoline-pyridazinooxazine chimera were prepared in good overall yield from phenethylamide 1 and 4,5-dichloropyridazin-3-one 2 via Smiles rearrangement and Pictet-Spengler cyclization.

Original languageEnglish (US)
Pages (from-to)3763-3773
Number of pages11
Issue number17
StatePublished - Apr 19 2004


  • Pyridazino[4,5-b][1,4]oxazine
  • Tetracyclic isoquinolines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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