An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines

Su Dong Cho; Yong Dae Park; Jeum Jong Kim; Woo Hong Joo; Motoo Shiro; Lothar Esser; J R Falck; Chuljin Ahn; Dong Soo Shin; Yong Jin Yoon

doi:10.1016/j.tet.2004.03.011

An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines

Su Dong Cho, Yong Dae Park, Jeum Jong Kim, Woo Hong Joo, Motoo Shiro, Lothar Esser, J R Falck, Chuljin Ahn, Dong Soo Shin, Yong Jin Yoon

Biochemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A series of fused isoquinoline-pyridazinooxazine chimera were prepared in good overall yield from phenethylamide 1 and 4,5-dichloropyridazin-3-one 2 via Smiles rearrangement and Pictet-Spengler cyclization.

Original language	English (US)
Pages (from-to)	3763-3773
Number of pages	11
Journal	Tetrahedron
Volume	60
Issue number	17
DOIs	https://doi.org/10.1016/j.tet.2004.03.011
State	Published - Apr 19 2004

Keywords

Pyridazino[4,5-b][1,4]oxazine
Tetracyclic isoquinolines

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2004.03.011

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title = "An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines",

abstract = "A series of fused isoquinoline-pyridazinooxazine chimera were prepared in good overall yield from phenethylamide 1 and 4,5-dichloropyridazin-3-one 2 via Smiles rearrangement and Pictet-Spengler cyclization.",

keywords = "Pyridazino[4,5-b][1,4]oxazine, Tetracyclic isoquinolines",

author = "Cho, {Su Dong} and Park, {Yong Dae} and Kim, {Jeum Jong} and Joo, {Woo Hong} and Motoo Shiro and Lothar Esser and Falck, {J R} and Chuljin Ahn and Shin, {Dong Soo} and Yoon, {Yong Jin}",

note = "Funding Information: This work was supported by Korea Research Foundation Grant (KRF-2002-C00008). ",

year = "2004",

month = apr,

day = "19",

doi = "10.1016/j.tet.2004.03.011",

language = "English (US)",

volume = "60",

pages = "3763--3773",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Limited",

number = "17",

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T1 - An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines

AU - Cho, Su Dong

AU - Park, Yong Dae

AU - Kim, Jeum Jong

AU - Joo, Woo Hong

AU - Shiro, Motoo

AU - Esser, Lothar

AU - Falck, J R

AU - Ahn, Chuljin

AU - Shin, Dong Soo

AU - Yoon, Yong Jin

N1 - Funding Information: This work was supported by Korea Research Foundation Grant (KRF-2002-C00008).

PY - 2004/4/19

Y1 - 2004/4/19

N2 - A series of fused isoquinoline-pyridazinooxazine chimera were prepared in good overall yield from phenethylamide 1 and 4,5-dichloropyridazin-3-one 2 via Smiles rearrangement and Pictet-Spengler cyclization.

AB - A series of fused isoquinoline-pyridazinooxazine chimera were prepared in good overall yield from phenethylamide 1 and 4,5-dichloropyridazin-3-one 2 via Smiles rearrangement and Pictet-Spengler cyclization.

KW - Pyridazino[4,5-b][1,4]oxazine

KW - Tetracyclic isoquinolines

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U2 - 10.1016/j.tet.2004.03.011

DO - 10.1016/j.tet.2004.03.011

M3 - Article

AN - SCOPUS:11144353979

SN - 0040-4020

VL - 60

SP - 3763

EP - 3773

JO - Tetrahedron

JF - Tetrahedron

IS - 17

ER -

An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines

Abstract

Keywords

ASJC Scopus subject areas

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