An essential role for the circadian-regulated gene Nocturnin in osteogenesis: The importance of local timekeeping in skeletal homeostasis

Anyonya R. Guntur, Masanobu Kawai, Phuong Le, Mary L. Bouxsein, Sheila Bornstein, Carla B. Green, Clifford J. Rosen

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The role of circadian proteins in regulating whole-body metabolism and bone turnover has been studied in detail and has led to the discovery of an elemental system for timekeeping involving the core genesClock, Bmal1, Per, and Cry. Nocturnin(Noc; Ccrn4l), a peripheral circadian-regulated gene has been shown to play a very important role in regulating adipogenesis by deadenylation of key mRNAs and intracytoplasmic transport of PPARγ. The role that it plays in osteogenesis has previously not been studied in detail. In this report we examinedin vitroandin vivoosteogenesis in the presence and absence ofNocand show that loss ofNocenhances bone formation and can rescue rosiglitazone-induced bone loss in mice. The circadian rhythm ofNocis likely to be an essential element of marrow stromal cell fate.

Original languageEnglish (US)
Pages (from-to)58-63
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1237
Issue number1
DOIs
StatePublished - Nov 2011

Keywords

  • Nocturnin
  • PPARγ
  • Rosiglitazone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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