TY - JOUR
T1 - An evaluation of space-time clustering in Hodgkin's disease
AU - Greenberg, Raymond S.
AU - Grufferman, Seymour
AU - Cole, Philip
N1 - Funding Information:
Ac~noa,/~,dUc,nlr~~rsã~re Windee bted to Dr George B. Hutchison for his guidance, to Mrs Thelma R. Levitan and Mr Ronald Bruno for their assistance, and to the administrative, record-room and medical staffs of the Boston area hospitals that participated in this study. This work was supported by a Specialized Center Grant (PO1 CA06373) and a Research Grant (ROl CA18103) from the National Cancer Institute, U.S.P.H.S. Seymour Grufferman was the recipient of an Individual Research Fellowship (F22 CA00279) and a Preventive Oncology Academic Award (K07 CA00726) from the National Cancer Institute.
PY - 1983
Y1 - 1983
N2 - A survey in Greater Boston identified 1577 new cases of histologically-confirmed Hodgkin's disease (HD) diagnosed from 1959 to 1973. The spatial position of each case was taken as the place of residence at diagnosis, and the temporal position as the month and year of diagnosis. Sufficient data for analysis were available for 1398 cases (89%). Space-time clustering was evaluated by three different methods: (a) Knox, (b) David and Barton and (c) Ederer, Myers and Mantel. When all HD cases were considered, none of these methods revealed statistically significant clustering. When stratification by risk factors was done, each of the techniques found significant clustering for various subgroups. Young adult cases (age 16-45 yr) tended to cluster more than older cases (age 46-70) and Catholics more than Jewish or Protestant cases. Rather than suggesting clustering at the time of HD diagnosis, the sporadic and inconsistently positive findings of this study may reflect case aggregation at the time of shared etiologic exposures, particularly if HD has a long and/or variable latent period.
AB - A survey in Greater Boston identified 1577 new cases of histologically-confirmed Hodgkin's disease (HD) diagnosed from 1959 to 1973. The spatial position of each case was taken as the place of residence at diagnosis, and the temporal position as the month and year of diagnosis. Sufficient data for analysis were available for 1398 cases (89%). Space-time clustering was evaluated by three different methods: (a) Knox, (b) David and Barton and (c) Ederer, Myers and Mantel. When all HD cases were considered, none of these methods revealed statistically significant clustering. When stratification by risk factors was done, each of the techniques found significant clustering for various subgroups. Young adult cases (age 16-45 yr) tended to cluster more than older cases (age 46-70) and Catholics more than Jewish or Protestant cases. Rather than suggesting clustering at the time of HD diagnosis, the sporadic and inconsistently positive findings of this study may reflect case aggregation at the time of shared etiologic exposures, particularly if HD has a long and/or variable latent period.
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U2 - 10.1016/0021-9681(83)90060-7
DO - 10.1016/0021-9681(83)90060-7
M3 - Article
C2 - 6826690
AN - SCOPUS:0020657772
SN - 0021-9681
VL - 36
SP - 257
EP - 262
JO - Journal of Chronic Diseases
JF - Journal of Chronic Diseases
IS - 3
ER -