An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets.

Karen I. Zeller, Anil G. Jegga, Bruce J. Aronow, Kathryn A O'Donnell-Mendell, Chi V. Dang

Research output: Contribution to journalArticle

348 Citations (Scopus)

Abstract

We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

Original languageEnglish (US)
JournalGenome Biology
Volume4
Issue number10
StatePublished - 2003

Fingerprint

genomics
Transcription Factors
transcription factors
Databases
gene
Genes
myc Genes
genes
prioritization
Chromatin Immunoprecipitation
Multigene Family
multigene family
chromatin
binding sites
Binding Sites
neoplasms
phylogeny
functional group
assays
cancer

ASJC Scopus subject areas

  • Genetics

Cite this

An integrated database of genes responsive to the Myc oncogenic transcription factor : identification of direct genomic targets. / Zeller, Karen I.; Jegga, Anil G.; Aronow, Bruce J.; O'Donnell-Mendell, Kathryn A; Dang, Chi V.

In: Genome Biology, Vol. 4, No. 10, 2003.

Research output: Contribution to journalArticle

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