TY - JOUR
T1 - An overview of MYC and its interactome
AU - Conacci-Sorrell, Maralice
AU - McFerrin, Lisa
AU - Eisenman, Robert N.
PY - 2014/1
Y1 - 2014/1
N2 - This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last,we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.
AB - This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last,we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.
UR - http://www.scopus.com/inward/record.url?scp=84889060963&partnerID=8YFLogxK
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U2 - 10.1101/cshperspect.a014357
DO - 10.1101/cshperspect.a014357
M3 - Article
C2 - 24384812
AN - SCOPUS:84889060963
SN - 2157-1422
VL - 4
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
IS - 1
ER -