An overview of MYC and its interactome

Maralice Conacci-Sorrell, Lisa McFerrin, Robert N. Eisenman

Research output: Contribution to journalArticle

172 Scopus citations

Abstract

This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last,we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Medicine
Volume4
Issue number1
DOIs
StatePublished - Jan 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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