An unusual case of elastofibroma oculi

Joseph K W Hsu, H. Dwight Cavanagh, W. Richard Green

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A 22-year-old female college student from the southwestern United States was first seen with progressive fluffy white growths over both corneas nasally and a history of chronic allergies and extensive sun, wind, and chlorine exposure as a competitive swimmer. The lesions were superficial, elevated, crescent-shaped, vascularized, and extended from the limbal conjunctiva onto the peripheral cornea nasally. The lesions were composed of an unencapsulated thick fibrovascular pannus with numerous fibrocytes, chronic inflammatory cells and mast cells, and abundant linear and wavy elastinophilic profiles, but no adipose tissue. Ultrastructurally, the elastinophilic structures were immature elastic fibers arranged in globules and bundles within a thick collagenous matrix. No mature elastic fibers were found. A few areas of elastotic degeneration were also found. This lesion resembled elastofibromas that have been reported more commonly in the subcapsular region and only once in the ocular region. Previous reports debated whether the elastic material in elastofibromas is derived from excessive production of elastic fibers by activated fibrocytes or from elastotic degeneration of collagen. In our case, both processes occur and are presumed to result from excessive ultraviolet radiation, wind and chlorine exposure, and perhaps, chronic inflammation; features that have been ascribed to the pathogenesis of pingueculae and pterygia.

Original languageEnglish (US)
Pages (from-to)112-119
Number of pages8
JournalCornea
Volume16
Issue number1
StatePublished - Jan 1997

Fingerprint

Elastic Tissue
Chlorine
Cornea
Pinguecula
Southwestern United States
Pterygium
Conjunctiva
Solar System
Mast Cells
Adipose Tissue
Hypersensitivity
Collagen
Radiation
Students
Inflammation
Growth

Keywords

  • Conjunctiva
  • Elastic fibers
  • Elastofibroma
  • Elastotic degeneration Electron microscopy
  • Pinguecula
  • Pseudopterygium
  • Pterygium

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Hsu, J. K. W., Cavanagh, H. D., & Green, W. R. (1997). An unusual case of elastofibroma oculi. Cornea, 16(1), 112-119.

An unusual case of elastofibroma oculi. / Hsu, Joseph K W; Cavanagh, H. Dwight; Green, W. Richard.

In: Cornea, Vol. 16, No. 1, 01.1997, p. 112-119.

Research output: Contribution to journalArticle

Hsu, JKW, Cavanagh, HD & Green, WR 1997, 'An unusual case of elastofibroma oculi', Cornea, vol. 16, no. 1, pp. 112-119.
Hsu JKW, Cavanagh HD, Green WR. An unusual case of elastofibroma oculi. Cornea. 1997 Jan;16(1):112-119.
Hsu, Joseph K W ; Cavanagh, H. Dwight ; Green, W. Richard. / An unusual case of elastofibroma oculi. In: Cornea. 1997 ; Vol. 16, No. 1. pp. 112-119.
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