Anaemia, iron deficiency and exercise: extended studies in human subjects

R. W. Charlton, D. Derman, B. Skikne, J. D. Torrance, S. R. Lynch, M. H. Sayers, S. Zwi, H. I. Goldman, A. Van As, G. Margo, J. T. Schneider, T. H. Bothwell

Research output: Contribution to journalArticle

17 Scopus citations


Ventilation and cardiac frequency were measured during repeated treadmill exercise in three healthy subjects over 36 weeks, before, during and after iron-deficiency anaemia was produced and after iron treatment. The haemoglobin and 2,3-diphosphoglycerate concentrations and the oxygen-binding (P 50) were measured. There was an inverse relationship between the haemoglobin concentrations and the 2.3-diphosphoglycerate concentrations and the P 50 values. The mean cardiac frequencies during the fourth to tenth minutes of exercise showed a negative correlation with the haemoglobin concentrations in all three subjects, and the mean minute ventilations in two of them.

Original languageEnglish (US)
Pages (from-to)537-541
Number of pages5
JournalClinical Science and Molecular Medicine
Issue number6
Publication statusPublished - 1977


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Charlton, R. W., Derman, D., Skikne, B., Torrance, J. D., Lynch, S. R., Sayers, M. H., ... Bothwell, T. H. (1977). Anaemia, iron deficiency and exercise: extended studies in human subjects. Clinical Science and Molecular Medicine, 53(6), 537-541.