Anaemia, iron deficiency and exercise: extended studies in human subjects

R. W. Charlton; D. Derman; B. Skikne; J. D. Torrance; S. R. Lynch; M. H. Sayers; S. Zwi; H. I. Goldman; A. Van As; G. Margo; J. T. Schneider; T. H. Bothwell

doi:10.1042/cs0530537

Anaemia, iron deficiency and exercise: extended studies in human subjects

R. W. Charlton, D. Derman, B. Skikne, J. D. Torrance, S. R. Lynch, M. H. Sayers, S. Zwi, H. I. Goldman, A. Van As, G. Margo, J. T. Schneider, T. H. Bothwell

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Abstract

Ventilation and cardiac frequency were measured during repeated treadmill exercise in three healthy subjects over 36 weeks, before, during and after iron-deficiency anaemia was produced and after iron treatment. The haemoglobin and 2,3-diphosphoglycerate concentrations and the oxygen-binding (P₅₀) were measured. There was an inverse relationship between the haemoglobin concentrations and the 2.3-diphosphoglycerate concentrations and the P₅₀ values. The mean cardiac frequencies during the fourth to tenth minutes of exercise showed a negative correlation with the haemoglobin concentrations in all three subjects, and the mean minute ventilations in two of them.

Original language	English (US)
Pages (from-to)	537-541
Number of pages	5
Journal	Unknown Journal
Volume	53
Issue number	6
DOIs	https://doi.org/10.1042/cs0530537
State	Published - 1977

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General Medicine

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title = "Anaemia, iron deficiency and exercise: extended studies in human subjects",

abstract = "Ventilation and cardiac frequency were measured during repeated treadmill exercise in three healthy subjects over 36 weeks, before, during and after iron-deficiency anaemia was produced and after iron treatment. The haemoglobin and 2,3-diphosphoglycerate concentrations and the oxygen-binding (P50) were measured. There was an inverse relationship between the haemoglobin concentrations and the 2.3-diphosphoglycerate concentrations and the P50 values. The mean cardiac frequencies during the fourth to tenth minutes of exercise showed a negative correlation with the haemoglobin concentrations in all three subjects, and the mean minute ventilations in two of them.",

author = "Charlton, {R. W.} and D. Derman and B. Skikne and Torrance, {J. D.} and Lynch, {S. R.} and Sayers, {M. H.} and S. Zwi and Goldman, {H. I.} and {Van As}, A. and G. Margo and Schneider, {J. T.} and Bothwell, {T. H.}",

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T1 - Anaemia, iron deficiency and exercise

T2 - extended studies in human subjects

AU - Charlton, R. W.

AU - Derman, D.

AU - Skikne, B.

AU - Torrance, J. D.

AU - Lynch, S. R.

AU - Sayers, M. H.

AU - Zwi, S.

AU - Goldman, H. I.

AU - Van As, A.

AU - Margo, G.

AU - Schneider, J. T.

AU - Bothwell, T. H.

PY - 1977

Y1 - 1977

N2 - Ventilation and cardiac frequency were measured during repeated treadmill exercise in three healthy subjects over 36 weeks, before, during and after iron-deficiency anaemia was produced and after iron treatment. The haemoglobin and 2,3-diphosphoglycerate concentrations and the oxygen-binding (P50) were measured. There was an inverse relationship between the haemoglobin concentrations and the 2.3-diphosphoglycerate concentrations and the P50 values. The mean cardiac frequencies during the fourth to tenth minutes of exercise showed a negative correlation with the haemoglobin concentrations in all three subjects, and the mean minute ventilations in two of them.

AB - Ventilation and cardiac frequency were measured during repeated treadmill exercise in three healthy subjects over 36 weeks, before, during and after iron-deficiency anaemia was produced and after iron treatment. The haemoglobin and 2,3-diphosphoglycerate concentrations and the oxygen-binding (P50) were measured. There was an inverse relationship between the haemoglobin concentrations and the 2.3-diphosphoglycerate concentrations and the P50 values. The mean cardiac frequencies during the fourth to tenth minutes of exercise showed a negative correlation with the haemoglobin concentrations in all three subjects, and the mean minute ventilations in two of them.

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Anaemia, iron deficiency and exercise: extended studies in human subjects

Abstract

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