Analogous Recognition of Phospholipids by Insect Phagocytes and Mammalian Macrophages

S. Ratner; A. J. Schroit; S. B. Vinson; I. J. Fidler

doi:10.3181/00379727-182-42339

Analogous Recognition of Phospholipids by Insect Phagocytes and Mammalian Macrophages

S. Ratner, A. J. Schroit, S. B. Vinson, I. J. Fidler

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23 Scopus citations

Abstract

Phagocytic cells from larvae of the moth Heliothis virescens and peritoneal macrophages of mice were observed to preferentially bind negatively charged phospholipid vesicles containing phosphatidylglycerol or phosphatidylserine as compared to neutral or positively charged vesicles. Since phagocytes have retained their primitive function of endocytosis throughout evolution, the recognition of negatively charged phospholipids may be a primitive mechanism for the identification of potential targets by macrophages.

Original language	English (US)
Pages (from-to)	272-276
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	182
Issue number	2
DOIs	https://doi.org/10.3181/00379727-182-42339
State	Published - Jun 1986

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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abstract = "Phagocytic cells from larvae of the moth Heliothis virescens and peritoneal macrophages of mice were observed to preferentially bind negatively charged phospholipid vesicles containing phosphatidylglycerol or phosphatidylserine as compared to neutral or positively charged vesicles. Since phagocytes have retained their primitive function of endocytosis throughout evolution, the recognition of negatively charged phospholipids may be a primitive mechanism for the identification of potential targets by macrophages.",

author = "S. Ratner and Schroit, {A. J.} and Vinson, {S. B.} and Fidler, {I. J.}",

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AU - Fidler, I. J.

PY - 1986/6

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AB - Phagocytic cells from larvae of the moth Heliothis virescens and peritoneal macrophages of mice were observed to preferentially bind negatively charged phospholipid vesicles containing phosphatidylglycerol or phosphatidylserine as compared to neutral or positively charged vesicles. Since phagocytes have retained their primitive function of endocytosis throughout evolution, the recognition of negatively charged phospholipids may be a primitive mechanism for the identification of potential targets by macrophages.

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Analogous Recognition of Phospholipids by Insect Phagocytes and Mammalian Macrophages

Abstract

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