Analogous recognition of phospholipids by insect phagocytes and mammalian macrophages (42339)

S. Ratner, A. J. Schroit, S. B. Vinson, I. J. Fidler

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Phagocytic cells from larvae of the moth Heliothis virescens and peritoneal macrophages of mice were observed to preferentially bind negatively charged phospholipid vesicles containing phosphatidylglycerol or phosphatidylserine as compared to neutral or positively charged vesicles. Since phagocytes have retained their primitive function of endocytosis throughout evolution, the recognition of negatively charged phospholipids may be a primitive mechanism for the identification of potential targets by macrophages.

Original languageEnglish (US)
Pages (from-to)272-276
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume182
Issue number2
StatePublished - 1986

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Macrophages
Phagocytes
Insects
Phospholipids
Phosphatidylglycerols
Moths
Phosphatidylserines
Peritoneal Macrophages
Endocytosis
Larva

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Analogous recognition of phospholipids by insect phagocytes and mammalian macrophages (42339). / Ratner, S.; Schroit, A. J.; Vinson, S. B.; Fidler, I. J.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 182, No. 2, 1986, p. 272-276.

Research output: Contribution to journalArticle

Ratner, S. ; Schroit, A. J. ; Vinson, S. B. ; Fidler, I. J. / Analogous recognition of phospholipids by insect phagocytes and mammalian macrophages (42339). In: Proceedings of the Society for Experimental Biology and Medicine. 1986 ; Vol. 182, No. 2. pp. 272-276.
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