Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis

Amer Awad, Bernhard Hemmer, Hans Peter Hartung, Bernd Kieseier, Jeffrey L. Bennett, Olaf Stuve

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The laboratory evaluation of cerebrospinal fluid (CSF) has been routinely employed as a diagnostic test in the diagnosis of neuroimmunological disorders such as multiple sclerosis (MS). Recently, CSF analyses in MS have garnered renewed interest as a tool for monitoring disease activity and prognosis. With the identification of patients that are very early in their disease course, namely patients with a radiologically isolated (RIS) or a clinically isolated syndrome (CIS), the true value of these evaluations has yet to be fully explored. Ultimately, the hope is that biomarkers within this compartment will be identified that will identify etiologic factors of MS and other inflammatory disorders of the central nervous system.In this review we discuss the history of CSF diagnostic tests and the most recent methodological advances. We also outline the potentially important diagnostic role and possible limitations of these tests.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Neuroimmunology
Volume219
Issue number1-2
DOIs
StatePublished - Feb 2010

Fingerprint

Multiple Sclerosis
Cerebrospinal Fluid
Routine Diagnostic Tests
Central Nervous System Diseases
Biomarkers
History

Keywords

  • Biomakers
  • Clinically isolated syndrome
  • Immunoglobulin
  • Multiple sclerosis
  • Myelin
  • Oligoclonal bands

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis. / Awad, Amer; Hemmer, Bernhard; Hartung, Hans Peter; Kieseier, Bernd; Bennett, Jeffrey L.; Stuve, Olaf.

In: Journal of Neuroimmunology, Vol. 219, No. 1-2, 02.2010, p. 1-7.

Research output: Contribution to journalArticle

Awad, Amer ; Hemmer, Bernhard ; Hartung, Hans Peter ; Kieseier, Bernd ; Bennett, Jeffrey L. ; Stuve, Olaf. / Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis. In: Journal of Neuroimmunology. 2010 ; Vol. 219, No. 1-2. pp. 1-7.
@article{0550fc0214bb4e5f826f94da9bdfa897,
title = "Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis",
abstract = "The laboratory evaluation of cerebrospinal fluid (CSF) has been routinely employed as a diagnostic test in the diagnosis of neuroimmunological disorders such as multiple sclerosis (MS). Recently, CSF analyses in MS have garnered renewed interest as a tool for monitoring disease activity and prognosis. With the identification of patients that are very early in their disease course, namely patients with a radiologically isolated (RIS) or a clinically isolated syndrome (CIS), the true value of these evaluations has yet to be fully explored. Ultimately, the hope is that biomarkers within this compartment will be identified that will identify etiologic factors of MS and other inflammatory disorders of the central nervous system.In this review we discuss the history of CSF diagnostic tests and the most recent methodological advances. We also outline the potentially important diagnostic role and possible limitations of these tests.",
keywords = "Biomakers, Clinically isolated syndrome, Immunoglobulin, Multiple sclerosis, Myelin, Oligoclonal bands",
author = "Amer Awad and Bernhard Hemmer and Hartung, {Hans Peter} and Bernd Kieseier and Bennett, {Jeffrey L.} and Olaf Stuve",
year = "2010",
month = "2",
doi = "10.1016/j.jneuroim.2009.09.002",
language = "English (US)",
volume = "219",
pages = "1--7",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis

AU - Awad, Amer

AU - Hemmer, Bernhard

AU - Hartung, Hans Peter

AU - Kieseier, Bernd

AU - Bennett, Jeffrey L.

AU - Stuve, Olaf

PY - 2010/2

Y1 - 2010/2

N2 - The laboratory evaluation of cerebrospinal fluid (CSF) has been routinely employed as a diagnostic test in the diagnosis of neuroimmunological disorders such as multiple sclerosis (MS). Recently, CSF analyses in MS have garnered renewed interest as a tool for monitoring disease activity and prognosis. With the identification of patients that are very early in their disease course, namely patients with a radiologically isolated (RIS) or a clinically isolated syndrome (CIS), the true value of these evaluations has yet to be fully explored. Ultimately, the hope is that biomarkers within this compartment will be identified that will identify etiologic factors of MS and other inflammatory disorders of the central nervous system.In this review we discuss the history of CSF diagnostic tests and the most recent methodological advances. We also outline the potentially important diagnostic role and possible limitations of these tests.

AB - The laboratory evaluation of cerebrospinal fluid (CSF) has been routinely employed as a diagnostic test in the diagnosis of neuroimmunological disorders such as multiple sclerosis (MS). Recently, CSF analyses in MS have garnered renewed interest as a tool for monitoring disease activity and prognosis. With the identification of patients that are very early in their disease course, namely patients with a radiologically isolated (RIS) or a clinically isolated syndrome (CIS), the true value of these evaluations has yet to be fully explored. Ultimately, the hope is that biomarkers within this compartment will be identified that will identify etiologic factors of MS and other inflammatory disorders of the central nervous system.In this review we discuss the history of CSF diagnostic tests and the most recent methodological advances. We also outline the potentially important diagnostic role and possible limitations of these tests.

KW - Biomakers

KW - Clinically isolated syndrome

KW - Immunoglobulin

KW - Multiple sclerosis

KW - Myelin

KW - Oligoclonal bands

UR - http://www.scopus.com/inward/record.url?scp=77249098682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77249098682&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2009.09.002

DO - 10.1016/j.jneuroim.2009.09.002

M3 - Article

C2 - 19782408

AN - SCOPUS:77249098682

VL - 219

SP - 1

EP - 7

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -