Anatomic MR imaging and functional diffusion tensor imaging of peripheral nerve tumors and tumorlike conditions

A. Chhabra, R. S. Thakkar, G. Andreisek, M. Chalian, A. J. Belzberg, J. Blakeley, A. Hoke, G. K. Thawait, J. Eng, J. A. Carrino

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Abstract

BACKGROUND AND PURPOSE: A number of benign and malignant peripheral nerve tumor and tumorlike conditions produce similar imaging features on conventional anatomic MR imaging. Functional MR imaging using DTI can increment the diagnostic performance in differentiation of these lesions. Our aim was to evaluate the role of 3T anatomic MR imaging and DTI in the characterization of peripheral nerve tumor and tumorlike conditions. MATERIALS AND METHODS: Twenty-nine patients (13 men, 16 women; mean age, 41±18 years; range, 11- 83 years) with a nerve tumor or tumorlike condition (25 benign, 5 malignant) underwent 3T MR imaging by using anatomic (n=29), functional diffusion, DWI (n=21), and DTI (n=24) techniques. Images were evaluated for image quality (3-point scale), ADC of the lesion, tractography, and fractional anisotropy of nerves with interobserver reliability in ADC and FA measurements. RESULTS: Nosignificant differences were observed in age (benign, 40±18 versus malignant, 45±19 years) and sex (benign, male/female= 12:12 versus malignant, male/female=3:2) (P>.05). All anatomic (29/29, 100%)MRimaging studies received 'good' quality; 20/21 (95%) DWI and 21/24 (79%) DTI studies received 'good' quality. ADC of benign lesions (1.848 ± 0.40 × 10-3 mm2/s) differed from that of malignant lesions (0.900 ± 0.25 × 10-3 mm2/s, P < .001) with excellent interobserver reliability (ICC = 0.988 [95% CI, 0.976-0.994]). There were no FA or ADC differences between men and women (P>.05). FA of involved nerves was lower than that in contralateral healthy nerves (P< .001) with excellent interobserver reliability (ICC = 0.970 [95% CI, 0.946-0.991]). ADC on DTI and DWI was not statistically different (P > .05), with excellent intermethod reliability (ICC = 0.943 [95% CI, 0.836-0.980]). Tractography differences were observed in benign and malignant lesions. CONCLUSIONS: 3T MR imaging and DTI are valuable methods for anatomic and functional evaluation of peripheral nerve lesions with excellent interobserver reliability. While tractography and low FA provide insight into neural integrity, low diffusivity values indicate malignancy in neural masses.

Original languageEnglish (US)
Pages (from-to)802-807
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume34
Issue number4
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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    Chhabra, A., Thakkar, R. S., Andreisek, G., Chalian, M., Belzberg, A. J., Blakeley, J., Hoke, A., Thawait, G. K., Eng, J., & Carrino, J. A. (2013). Anatomic MR imaging and functional diffusion tensor imaging of peripheral nerve tumors and tumorlike conditions. American Journal of Neuroradiology, 34(4), 802-807. https://doi.org/10.3174/ajnr.A3316