Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract

G. J. Wirth, A. Haitel, M. Moschini, F. Soria, T. Klatte, M. R. Hassler, K. Bensalah, A. Briganti, J. A. Karam, Yair Lotan, Vitaly Margulis, J. D. Raman, M. Remzi, N. Rioux-Leclercq, B. D. Robinson, M. Rouprêt, C. G. Wood, S. F. Shariat

Research output: Contribution to journalArticle

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Abstract

Purpose: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). Methods: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: Overall, AR was expressed in 11 % of tumors. AR expression was significantly associated with tumor necrosis as well as sessile and multifocal tumor growth but not with RFS, CSS or OS. AR was detected nearly twice as often in tumors of the ureter than of the pelvicalyceal system (p = 0.005). Subgroup analyses showed that the significant associations of AR with unfavorable pathologic features were exclusively attributable to tumors located in the ureter. However, in both ureteral and pelvicalyceal tumors, AR status was independent of RFS, CSS and OS. Conclusions: In this cohort of patients treated with RNU, AR expression was found in approximately 10 % of UTUCs, twice as often in ureteral than in pelvicalyceal tumors. While AR expression had no impact on postoperative prognosis, it was significantly associated with unfavorable pathologic features in ureteral tumors. Steroid hormone signaling might be relevant for future investigations of differences between ureteral and pelvicalyceal tumors.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalWorld Journal of Urology
DOIs
StateAccepted/In press - Oct 11 2016

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Androgen Receptors
Urinary Tract
Carcinoma
Neoplasms
Survival
Ureter
Recurrence
Necrosis
Steroids
Hormones

Keywords

  • Androgen receptor
  • Radical nephroureterectomy
  • Tissue microarray
  • Upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract. / Wirth, G. J.; Haitel, A.; Moschini, M.; Soria, F.; Klatte, T.; Hassler, M. R.; Bensalah, K.; Briganti, A.; Karam, J. A.; Lotan, Yair; Margulis, Vitaly; Raman, J. D.; Remzi, M.; Rioux-Leclercq, N.; Robinson, B. D.; Rouprêt, M.; Wood, C. G.; Shariat, S. F.

In: World Journal of Urology, 11.10.2016, p. 1-7.

Research output: Contribution to journalArticle

Wirth, GJ, Haitel, A, Moschini, M, Soria, F, Klatte, T, Hassler, MR, Bensalah, K, Briganti, A, Karam, JA, Lotan, Y, Margulis, V, Raman, JD, Remzi, M, Rioux-Leclercq, N, Robinson, BD, Rouprêt, M, Wood, CG & Shariat, SF 2016, 'Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract', World Journal of Urology, pp. 1-7. https://doi.org/10.1007/s00345-016-1946-8
Wirth, G. J. ; Haitel, A. ; Moschini, M. ; Soria, F. ; Klatte, T. ; Hassler, M. R. ; Bensalah, K. ; Briganti, A. ; Karam, J. A. ; Lotan, Yair ; Margulis, Vitaly ; Raman, J. D. ; Remzi, M. ; Rioux-Leclercq, N. ; Robinson, B. D. ; Rouprêt, M. ; Wood, C. G. ; Shariat, S. F. / Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract. In: World Journal of Urology. 2016 ; pp. 1-7.
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abstract = "Purpose: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). Methods: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: Overall, AR was expressed in 11 {\%} of tumors. AR expression was significantly associated with tumor necrosis as well as sessile and multifocal tumor growth but not with RFS, CSS or OS. AR was detected nearly twice as often in tumors of the ureter than of the pelvicalyceal system (p = 0.005). Subgroup analyses showed that the significant associations of AR with unfavorable pathologic features were exclusively attributable to tumors located in the ureter. However, in both ureteral and pelvicalyceal tumors, AR status was independent of RFS, CSS and OS. Conclusions: In this cohort of patients treated with RNU, AR expression was found in approximately 10 {\%} of UTUCs, twice as often in ureteral than in pelvicalyceal tumors. While AR expression had no impact on postoperative prognosis, it was significantly associated with unfavorable pathologic features in ureteral tumors. Steroid hormone signaling might be relevant for future investigations of differences between ureteral and pelvicalyceal tumors.",
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T1 - Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract

AU - Wirth, G. J.

AU - Haitel, A.

AU - Moschini, M.

AU - Soria, F.

AU - Klatte, T.

AU - Hassler, M. R.

AU - Bensalah, K.

AU - Briganti, A.

AU - Karam, J. A.

AU - Lotan, Yair

AU - Margulis, Vitaly

AU - Raman, J. D.

AU - Remzi, M.

AU - Rioux-Leclercq, N.

AU - Robinson, B. D.

AU - Rouprêt, M.

AU - Wood, C. G.

AU - Shariat, S. F.

PY - 2016/10/11

Y1 - 2016/10/11

N2 - Purpose: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). Methods: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: Overall, AR was expressed in 11 % of tumors. AR expression was significantly associated with tumor necrosis as well as sessile and multifocal tumor growth but not with RFS, CSS or OS. AR was detected nearly twice as often in tumors of the ureter than of the pelvicalyceal system (p = 0.005). Subgroup analyses showed that the significant associations of AR with unfavorable pathologic features were exclusively attributable to tumors located in the ureter. However, in both ureteral and pelvicalyceal tumors, AR status was independent of RFS, CSS and OS. Conclusions: In this cohort of patients treated with RNU, AR expression was found in approximately 10 % of UTUCs, twice as often in ureteral than in pelvicalyceal tumors. While AR expression had no impact on postoperative prognosis, it was significantly associated with unfavorable pathologic features in ureteral tumors. Steroid hormone signaling might be relevant for future investigations of differences between ureteral and pelvicalyceal tumors.

AB - Purpose: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). Methods: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: Overall, AR was expressed in 11 % of tumors. AR expression was significantly associated with tumor necrosis as well as sessile and multifocal tumor growth but not with RFS, CSS or OS. AR was detected nearly twice as often in tumors of the ureter than of the pelvicalyceal system (p = 0.005). Subgroup analyses showed that the significant associations of AR with unfavorable pathologic features were exclusively attributable to tumors located in the ureter. However, in both ureteral and pelvicalyceal tumors, AR status was independent of RFS, CSS and OS. Conclusions: In this cohort of patients treated with RNU, AR expression was found in approximately 10 % of UTUCs, twice as often in ureteral than in pelvicalyceal tumors. While AR expression had no impact on postoperative prognosis, it was significantly associated with unfavorable pathologic features in ureteral tumors. Steroid hormone signaling might be relevant for future investigations of differences between ureteral and pelvicalyceal tumors.

KW - Androgen receptor

KW - Radical nephroureterectomy

KW - Tissue microarray

KW - Upper tract urothelial carcinoma

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