AngiomiRs-Key regulators of angiogenesis

Shusheng Wang, Eric N. Olson

Research output: Contribution to journalReview article

303 Scopus citations

Abstract

The formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as ischemia and cancer. Recent studies have revealed important roles for miRNAs in regulating endothelial cell (EC) function, especially angiogenesis. Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown to regulate angiogenesis in vivo. miRNA-126, an EC-restricted miRNA, regulates vascular integrity and developmental angiogenesis. miR-378, miR-296, and the miR-17∼92 cluster contribute to tumor angiogenesis. Manipulating angiomiRs in the settings of pathological vascularization represents a new therapeutic approach.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume19
Issue number3
DOIs
StatePublished - Jun 1 2009

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ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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