Ankylosing spondylitis: New improved treatment, new improved models

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Ankylosing spondylitis (AS) is an underdiagnosed chronic inflammatory disease. The etiology is largely genetic, with strong association with the allele HLA-B27. Pathogenesis is poorly understood, but dramatic benefit from anti-TNF therapy indicates that the cytokine TNF is centrally involved. Rodent models are available to study several aspects of AS pathogenesis: the role HLA-B27, the process of spinal and peripheral joint calcification, immune responses to candidate antigens and the role of TNF.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalDrug Discovery Today: Disease Models
Volume3
Issue number1
DOIs
StatePublished - Apr 26 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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