Annexin i targets S100C to early endosomes

Joachim Seemann, Klaus Weber, Volker Gerke

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Immunofluorescence and subcellular fractionation localize annexin I and the EF Band protein S100C to the same membranous structures which in part correspond to transferrin receptor-positive endosomes. The association of S100C with endosomal membranes is strictly dependent on annexin I binding since a D91stop-S100C mutant protein, in which the residues essential for annexin I binding have been removed, fails to co-localize with membraneous structures. This indicates that annexin I and S100C form a complex in vivo and that the endosomal localization of this complex is mediated through an interaction of annexin I with the endosomal membrane.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalFEBS Letters
Volume413
Issue number1
DOIs
StatePublished - Aug 11 1997

Keywords

  • Annexin
  • Ca binding protein
  • EF hand
  • Endocytosis

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Annexin i targets S100C to early endosomes'. Together they form a unique fingerprint.

  • Cite this