Annexin i targets S100C to early endosomes

Joachim Seemann, Klaus Weber, Volker Gerke

Research output: Contribution to journalArticle

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Abstract

Immunofluorescence and subcellular fractionation localize annexin I and the EF Band protein S100C to the same membranous structures which in part correspond to transferrin receptor-positive endosomes. The association of S100C with endosomal membranes is strictly dependent on annexin I binding since a D91stop-S100C mutant protein, in which the residues essential for annexin I binding have been removed, fails to co-localize with membraneous structures. This indicates that annexin I and S100C form a complex in vivo and that the endosomal localization of this complex is mediated through an interaction of annexin I with the endosomal membrane.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalFEBS Letters
Volume413
Issue number1
DOIs
Publication statusPublished - Aug 11 1997

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Keywords

  • Annexin
  • Ca binding protein
  • EF hand
  • Endocytosis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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